ArticleScience signaling2011
Phosphorylation of Mad controls competition between wingless and BMP signaling.
Article in Science signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera.Channels (Austin, Tex.) · 2025Review
- Review
- Intracellular Communication among Morphogen Signaling Pathways during Vertebrate Body Plan Formation.Genes · 2020Review
- Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates.Developmental cell · 2019Review
- TGF-β Family Signaling inCold Spring Harbor perspectives in biology · 2017Review
- Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways.Cold Spring Harbor perspectives in biology · 2017Review
- Drosophila Dullard functions as a Mad phosphatase to terminate BMP signaling.Scientific reports · 2016Article
- Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin.Cell communication and signaling : CCS · 2016Article
- Efficient retina formation requires suppression of both Activin and BMP signaling pathways in pluripotent cells.Biology open · 2015Article
- Drosophila's contribution to stem cell research.F1000Research · 2015Review
- Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues.Scientific reports · 2014Article
- Strategies for exploring TGF-β signaling in Drosophila.Methods (San Diego, Calif.) · 2014Review
- Ter94/VCP is a novel component involved in BMP signaling.PloS one · 2014Article
- New insights into extracellular and post-translational regulation of TGF-β family signalling pathways.Journal of biochemistry · 2013Review
- Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins.The Journal of biological chemistry · 2013Article
- Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts.Bone · 2013Article
- Article
- An inwardly rectifying K+ channel is required for patterning.Development (Cambridge, England) · 2012Article
- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Bone morphogenetic proteins (BMPs) and Wnts are growth factors that provide essential patterning signals for cell proliferation and differentiation. Here, we describe a molecular mechanism by which the phosphorylation state of the Drosophila transcription factor Mad determines its ability to transduce either BMP or Wingless (Wg) signals. Previously, Mad was thought to function in gene transcription only when phosphorylated by BMP receptors. We found that the unphosphorylated form of Mad was required for canonical Wg signaling by interacting with the Pangolin-Armadillo transcriptional complex. Phosphorylation of the carboxyl terminus of Mad by BMP receptor directed Mad toward BMP signaling, thereby preventing Mad from functioning in the Wg pathway. The results show that Mad has distinct signal transduction roles in the BMP and Wnt pathways depending on its phosphorylation state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.