ArticleScience signaling2011
Load-induced modulation of signal transduction networks.
Article in Science signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Transient frequency preference responses in cell signaling systems.NPJ systems biology and applications · 2024Article
- A programmable reaction-diffusion system for spatiotemporal cell signaling circuit design.Cell · 2024Article
- A nested bistable module within a negative feedback loop ensures different types of oscillations in signaling systems.Scientific reports · 2023Article
- Frequency-preference response in covalent modification cycles under substrate sequestration conditions.NPJ systems biology and applications · 2021Article
- Analysis of mechanotransduction dynamics during combined mechanical stimulation and modulation of the extracellular-regulated kinase cascade uncovers hidden information within the signalling noise.Interface focus · 2021Article
- Article
- Signaling Architectures that Transmit Unidirectional Information Despite Retroactivity.Biophysical journal · 2017Article
- Modular bond-graph modelling and analysis of biomolecular systems.IET systems biology · 2016Article
- Signaling cascades transmit information downstream and upstream but unlikely simultaneously.BMC systems biology · 2016Article
- Control theory meets synthetic biology.Journal of the Royal Society, Interface · 2016Review
- How to train your microbe: methods for dynamically characterizing gene networks.Current opinion in microbiology · 2015Review
- Retroactivity in the Context of Modularly Structured Biomolecular Systems.Frontiers in bioengineering and biotechnology · 2015Review
- A load driver device for engineering modularity in biological networks.Nature biotechnology · 2014Article
- A technique for determining the signs of sensitivities of steady states in chemical reaction networks.IET systems biology · 2014Article
- A quantitative framework for the forward design of synthetic miRNA circuits.Nature methods · 2014Article
- A 'resource allocator' for transcription based on a highly fragmented T7 RNA polymerase.Molecular systems biology · 2014Article
- Paradoxical results in perturbation-based signaling network reconstruction.Biophysical journal · 2014Article
- Loads bias genetic and signaling switches in synthetic and natural systems.PLoS computational biology · 2014Article
- Modular composition of gene transcription networks.PLoS computational biology · 2014Article
- Segregation and crosstalk of D1 receptor-mediated activation of ERK in striatal medium spiny neurons upon acute administration of psychostimulants.PLoS computational biology · 2014Article
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6 authors.
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Abstract
Biological signal transduction networks are commonly viewed as circuits that pass along information--in the process amplifying signals, enhancing sensitivity, or performing other signal-processing tasks--to transcriptional and other components. Here, we report on a "reverse-causality" phenomenon, which we call load-induced modulation. Through a combination of analytical and experimental tools, we discovered that signaling was modulated, in a surprising way, by downstream targets that receive the signal and, in doing so, apply what in physics is called a load. Specifically, we found that non-intuitive changes in response dynamics occurred for a covalent modification cycle when load was present. Loading altered the response time of a system, depending on whether the activity of one of the enzymes was maximal and the other was operating at its minimal rate or whether both enzymes were operating at submaximal rates. These two conditions, which we call "limit regime" and "intermediate regime," were associated with increased or decreased response times, respectively. The bandwidth, the range of frequency in which the system can process information, decreased in the presence of load, suggesting that downstream targets participate in establishing a balance between noise-filtering capabilities and a circuit's ability to process high-frequency stimulation. Nodes in a signaling network are not independent relay devices, but rather are modulated by their downstream targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.