ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2011
Prognostic impact of body mass index stratified by smoking status in patients with esophageal adenocarcinoma.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Association of Obesity With Survival Outcomes in Patients With Cancer: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Impact of high body mass index on surgical outcomes and long-term survival among patients undergoing esophagectomy: A meta-analysis.Medicine · 2018Pooled it
- Positive Effect of Higher Adult Body Mass Index on Overall Survival of Digestive System Cancers Except Pancreatic Cancer: A Systematic Review and Meta-Analysis.BioMed research international · 2017Pooled it
- The impact of body mass index on complication and survival in resected oesophageal cancer: a clinical-based cohort and meta-analysis.British journal of cancer · 2013Pooled it
- Comparing intraoperative ultrasound and wire-guided localisation for skin cancer metastases: impacts on patient safety, outcomes, costs, and implementation.World journal of surgical oncology · 2026Article
- Obesity Control and Cancer Prevention in China: Insights from the Weight Management Year.China CDC weekly · 2025Article
- Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients.Cell communication and signaling : CCS · 2025Article
- Impact of obesity and white adipose tissue inflammation on the omental microenvironment in endometrial cancer.Cancer · 2022Article
- The Impact of Morbid Obesity on the Health Outcomes of Hospital Inpatients: An Observational Study.Journal of clinical medicine · 2021Article
- Survival outcomes for patients with four treatments in stages I-III esophageal squamous cell carcinoma: a SEER analysis.Translational cancer research · 2021Article
- Adipose tissue area as a predictor for the efficacy of apatinib in platinum-resistant ovarian cancer: an exploratory imaging biomarker analysis of the AEROC trial.BMC medicine · 2020Article
- Clinical characteristics and survival of 5283 esophageal cancer patients: A multicenter study from eighteen hospitals across six regions in China.Cancer communications (London, England) · 2020Article
- Prediagnostic adult body mass index change and esophageal adenocarcinoma survival.Cancer medicine · 2020Article
- Autocrine action of adipokine omentin-1 in the SW480 colon cancer cell line.Oncology letters · 2020Article
- Serum Levels of 25-Hydroxyvitamin D at Diagnosis Are Not Associated with Overall Survival in Esophageal Adenocarcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Temporal Changes in Esophageal Cancer Mortality by Geographic Region: A Population-based Analysis.Cureus · 2018Article
- The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma.Scientific reports · 2018Article
- The Impact of Obesity on Breast Cancer.Current oncology reports · 2018Review
- Excessive Pretreatment Weight Loss Is a Risk Factor for the Survival Outcome of Esophageal Carcinoma Patients Undergoing Radical Surgery and Postoperative Adjuvant Chemotherapy.Canadian journal of gastroenterology & hepatology · 2018Article
- CT-based assessment of visceral adiposity and outcomes for esophageal adenocarcinoma.Journal of gastrointestinal oncology · 2017Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
purposeGiven that smoking affects body mass index (BMI) and survival, stratification by smoking status may be required to determine the true prognostic impact of BMI. Although obesity increases risk for developing esophageal adenocarcinoma (EAC), the prognostic influence of obesity and its potential modification by smoking status is unknown in this disease. PATIENTS AND
methodsAll patients (N = 778) underwent potentially curative esophagectomy. BMI was calculated using measured height and weight at surgery and categorized as obese (≥ 30 kg/m(2)), overweight (25 to 29.9 kg/m(2)), or normal (18.5 to 24.9 kg/m(2)). Cigarette smoking was categorized as never or ever. The association of BMI with disease-specific survival (DSS), disease-free survival (DFS), and overall survival (OS) was determined by Cox regression.
resultsExcess BMI was significantly associated with DSS in a manner that differed substantially by smoking status (P for interaction = .023). Among never smokers, obesity was significantly associated with adverse DSS (hazard ratio [HR] = 2.11; 95% CI, 1.31 to 3.43; P = .002), DFS (HR = 2.03; 95% CI, 1.30 to 3.18; P = .002), and OS (HR = 1.97; 95% CI, 1.24 to 3.14; P = .004), as compared with normal weight, after adjusting for covariates. By contrast, among ever smokers, obesity was not prognostic, and overweight status was significantly associated with favorable survival in univariate, but not multivariate, analysis.
conclusionObesity among never smokers was independently associated with two-fold worsening of DSS, DFS, and OS after surgery for EAC, after adjusting for known prognostic factors. These data, in one of the largest reported resected EAC cohorts, are the first to show an adverse prognostic impact of obesity in EAC.
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