ArticleThe Journal of biological chemistry2011
Inflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review.PloS one · 2017Pooled it
- Risk Assessment of Trigonelline in Coffee and Coffee By-Products.Molecules (Basel, Switzerland) · 2023Review
- Complexification of In Vitro Models of Intestinal Barriers, A True Challenge for a More Accurate Alternative Approach.International journal of molecular sciences · 2023Review
- The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis.Frontiers in immunology · 2023Review
- How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer.Reviews of physiology, biochemistry and pharmacology · 2021Review
- Overexpression of Nrf2 promotes colon cancer progression via ERK and AKT signaling pathways.Annals of surgical treatment and research · 2020Article
- DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer.Cell death and differentiation · 2019Article
- The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth.Toxicology and applied pharmacology · 2019Article
- CDK Blockade Using AT7519 Suppresses Acute Myeloid Leukemia Cell Survival through the Inhibition of Autophagy and Intensifies the Anti-leukemic Effect of Arsenic Trioxide.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation.The Journal of cell biology · 2018Article
- Fungal melanin stimulates surfactant protein D-mediated opsonization of and host immune response toThe Journal of biological chemistry · 2018Article
- Article
- Radiation-Induced Alterations in the Recurrent Glioblastoma Microenvironment: Therapeutic Implications.Frontiers in oncology · 2018Review
- The protective effects of Zhen-Wu-Tang against cisplatin-induced acute kidney injury in rats.PloS one · 2017Article
- miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer.Oncoimmunology · 2016Article
- Article
- The Crosstalk between Nrf2 and TGF-β1 in the Epithelial-Mesenchymal Transition of Pancreatic Duct Epithelial Cells.PloS one · 2015Article
- Raf/ERK/Nrf2 signaling pathway and MMP-7 expression involvement in the trigonelline-mediated inhibition of hepatocarcinoma cell migration.Food & nutrition research · 2015Article
- Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.The Journal of biological chemistry · 2014Article
- Cytoprotection "gone astray": Nrf2 and its role in cancer.OncoTargets and therapy · 2014Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptation of epithelial cells to persistent oxidative stress plays an important role in inflammation-associated carcinogenesis. This adaptation process involves activation of Nrf2 (nuclear factor-E2-related factor-2), which has been recently shown to contribute to carcinogenesis through the induction of proteasomal gene expression and proteasome activity. To verify this possible link between inflammation, oxidative stress, and Nrf2-dependent proteasome activation, we explored the impact of inflammatory (M1) macrophages on the human colon epithelial cell line NCM460. Transwell cocultures with macrophages differentiated from granulocyte monocyte-colony-stimulating factor-treated monocytes led to an increased activity of Nrf2 in NCM460 cells along with an elevated proteasome activity. This higher proteasome activity resulted from Nrf2-dependent induction of proteasomal gene expression, as shown for the 19 and 20 S subunit proteins S5a and α5, respectively. These effects of macrophage coculture were preceded by an increase of reactive oxygen species in cocultured NCM460 cells and could be blocked by catalase or by the reactive oxygen species scavenger Tiron, whereas transient treatment of NCM460 cells with H(2)O(2) similarly led to Nrf2-dependent proteasome activation. Through the Nrf2-dependent increase of proteasomal gene expression and proteasome activity, the sensitivity of NCM460 cells to tumor necrosis factor-related apoptosis-inducing ligand- or irinotecan-induced apoptosis declined. These findings indicate that inflammatory conditions such as the presence of M1 macrophages and the resulting oxidative stress are involved in the Nrf2-dependent gain of proteasome activity in epithelial cells, e.g. colonocytes, giving rise of greater resistance to apoptosis. This mechanism might contribute to inflammation-associated carcinogenesis, e.g. of the colon.
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