ArticleJournal of natural medicines2012
Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats.
Article in Journal of natural medicines, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 78 citations in OpenAlex.
- Exploring Nutritional Properties, Bioactive Compounds, and Potential Applications ofFoods (Basel, Switzerland) · 2026Review
- An Ethnobotanical Survey and Pharmacological and Toxicity Review of Medicinal Plants Used in the Management of Obesity in the North Central Zone of Nigeria.Journal of obesity · 2025Article
- Effects of tamarind pulp powder supplementation on growth performance, haemato-immunological parameters, and immune-related gene expression in pacific white leg shrimpIranian journal of veterinary research · 2025Article
- Effects of Ethanolic and Aqueous Extracts ofNutrients · 2023Article
- Protective and Therapeutic Effects of Orlistat on Metabolic Syndrome and Oxidative Stress in High-Fat Diet-Induced Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Rats: Role on Nrf2 Activation.Veterinary sciences · 2021Article
- Lettuce-avicularin treatment reverses insulin resistance through stimulation of glycolytic kinases and insulin signaling molecules.Iranian journal of basic medical sciences · 2021Article
- Polyphenols and ω-3 PUFAs: Beneficial Outcomes to Obesity and Its Related Metabolic Diseases.Frontiers in nutrition · 2021Review
- Evaluation on the Effects ofInternational journal of preventive medicine · 2020Article
- The intake of an extract from seeds ofHeliyon · 2020Article
- Countrywide Survey of Plants Used for Liver Disease Management by Traditional Healers in Burkina Faso.Frontiers in pharmacology · 2020Article
- Endoplasmic Reticulum Stress-Induced Resistance to Doxorubicin Is Reversed by Mulberry Leaf Polyphenol Extract in Hepatocellular Carcinoma through Inhibition of COX-2.Antioxidants (Basel, Switzerland) · 2019Article
- Mangosteen (Garcinia mangostana) flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obese rats.BMC complementary and alternative medicine · 2019Article
- Tamarind: A diet-based strategy against lifestyle maladies.Food science & nutrition · 2019Review
- Postprandial Glycemic and Insulinemic Effects of the Addition of Aqueous Extracts of Dried Corn Silk, Cumin Seed Powder or Tamarind Pulp, in Two Forms, Consumed with High Glycemic Index Rice.Foods (Basel, Switzerland) · 2019Article
- Mulberry Fruit Extract Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) through Inhibition of Mitochondrial Oxidative Stress in Rats.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Lipolytic effect of novel extracts from mulberry (Laboratory animal research · 2017Article
- Six-Month Chronic Toxicity Study of Tamarind Pulp (Tamarindus indica L.) Water Extract.Scientia pharmaceutica · 2017Article
- Anti-obesity effect of ethanolic extract from Cosmos caudatus Kunth leaf in lean rats fed a high fat diet.BMC complementary and alternative medicine · 2017Article
- Germinated brown rice ameliorates obesity in high-fat diet induced obese rats.BMC complementary and alternative medicine · 2016Article
- Ethnobotanical Study of Medicinal Plants Used as Anti-Obesity Remedies in the Nomad and Hunter Communities of Burkina Faso.Medicines (Basel, Switzerland) · 2016Article
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7 authors at 2 institutions in 1 country.
Funding
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Abstract
Obesity and overweight are associated with atherosclerosis, fatty liver, hyperlipemia, diabetes mellitus, and various types of cancer. The global prevalence of overweight and obesity has reached epidemic proportions. Here, we investigated the effect of Tamarindus indica pulp aqueous extract (TIE) in diet-induced obese Sprague-Dawley rats. The animals were divided into five groups and labeled as follows: the normal control (NC) group received normal diet; the positive control (PC) group received high-fat diet; and the TIE 5, 25, and 50 groups, after the induction of obesity via a high-fat diet, received TIE at 5, 25, or 50 mg/kg orally for 10 weeks. It was observed that TIE decreased the levels of plasma total cholesterol, low-density lipoprotein (LDL), and triglyceride, and increased high-density lipoprotein (HDL), with the concomitant reduction of body weight. Moreover, TIE decreased plasma leptin and reduced fatty acid synthase (FAS) activity and enhanced the efficiency of the antioxidant defense system. TIE exhibits antiobesity effects, as indicated by a significant reduction in adipose tissue weights, as well as lowering the degree of hepatic steatosis in the obesity-induced rats. The extract possesses hepatoprotective activity, as it reversed the plasma liver enzymes level elevation prior to the high-fat diet. In conclusion, TIE improved obesity-related parameters in blood, liver, and adipose tissue in a rat model and suppressed obesity induced by a high-fat diet, possibly by regulating lipid metabolism and lowering plasma leptin and FAS levels. A dose-dependant effect of TIE is detected, where TIE at 50 mg/kg showed the most prominent effect, followed by TIE at 25 mg/kg and, subsequently, 5 mg/kg.
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