ReviewCurrent topics in microbiology and immunology2012
The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression.
Review in Current topics in microbiology and immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors.Cells · 2021Review
- Understanding the Relevance of DNA Methylation Changes in Immune Differentiation and Disease.Genes · 2020Review
- Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages.Nature immunology · 2015Article
- From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells.Immunologic research · 2014Review
- LMO2 induces T-cell leukemia with epigenetic deregulation of CD4.Experimental hematology · 2014Article
- Transcriptional regulation in the immune system: a status report.Trends in immunology · 2014Article
- Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.Nature communications · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Developing αβ T cells choose between the helper and cytotoxic lineages, depending upon the specificity of their T cell receptors for MHC molecules. The expression of the CD4 co-receptor on helper cells and the CD8 co-receptor on cytotoxic cells is intimately linked to this decision, and their regulation at the transcriptional level has been the subject of intense study to better understand lineage choice. Indeed, as the fate of developing T cells is decided, the expression status of these genes is accordingly locked. Genetic models have revealed important transcriptional elements and the ability to manipulate these elements in the framework of development has added a new perspective on the temporal nature of their function and the epigenetic maintenance of gene expression. We examine here novel insights into epigenetic mechanisms that have arisen through the study of these genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.