ArticleNeurocritical care2012
Cerebral infarction in adults with bacterial meningitis.
Article in Neurocritical care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Outcomes of adults with community-acquired bacterial meningitis in the Netherlands: a prospective nationwide cohort study.The Lancet regional health. Europe · 2026Article
- Article
- Cerebral vasculitis as a severe complication of acute infectious meningoencephalitis-a case series of five different pathogens.Wiener medizinische Wochenschrift (1946) · 2025Article
- Mid-Regional Proadrenomedullin in Cerebrospinal Fluid Is a Reliable Diagnostic and Prognostic Marker for Acute Meningoencephalitis and Neurological Disorders.Journal of clinical laboratory analysis · 2025Article
- The Stroke Alert that Wasn't: Lessons Learned from Meningitis-Associated Vasospasm.Neurocritical care · 2025Article
- Delayed cerebral infarction in pneumococcal meningitis due to postinfectious vasculitis: A case report.Medicine · 2025Article
- Cerebrovascular Complications in Bacterial Meningitis.Stroke (Hoboken, N.J.) · 2025Review
- Stroke from Infection.Cerebrovascular diseases extra · 2025Review
- Article
- Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study.Annals of intensive care · 2024Article
- Review
- Prognostic value of cranial ultrasound findings in infants aged <90 days with bacterial meningitis: a single-centre retrospective cohort study.BMJ paediatrics open · 2024Article
- Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles.Nature communications · 2024Article
- Factors associated with afebrile presentation and delayed defervescence of bacterial meningitis in children under 3 years of age: a multi-centre retrospective analysis.BMC pediatrics · 2023Article
- Cerebrovascular complications in patients with community-acquired bacterial meningitis: occurrence and associated factors in the COMBAT multicenter prospective cohort.BMC infectious diseases · 2023Article
- The role of plasminogen activator inhibitor-2 in pneumococcal meningitis.Acta neuropathologica communications · 2022Article
- Combined Bacterial Meningitis and Infective Endocarditis: When Should We Search for the Other When Either One is Diagnosed?Infectious diseases and therapy · 2022Article
- Pneumococcal Meningitis in Adults: A Prospective Nationwide Cohort Study Over a 20-year Period.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- MR vessel wall imaging in cerebral bacterial and fungal infections.Neuroradiology · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate clinical features and prognostic factors of cerebral infarctions in adults with community-acquired bacterial meningitis.
methodAn observational cross-sectional study, including 696 patients of whom 174 had cerebral infarction, from a prospective nationwide cohort of community-acquired bacterial meningitis (period, 1998-2002), confirmed by culture of cerebral spinal fluid (CSF) in patients aged over 16 years. Two investigators independently determined the presence of infarction.
resultCerebral infarction occurred in 174 episodes (25%), with a high inter-rater agreement for determining the presence of cerebral infarction (kappa 0.95). Cerebral infarctions occurred in 128 of 352 patients (36%) with pneumococcal meningitis, in 22 of 257 (9%) with meningococcal meningitis and in 24 of 87 patients (28%) with meningitis caused by other bacteria. Patients with infarctions were older (P < 0.001) and often presented with predisposing conditions, such as otitis and/or sinusitis (P = 0.001) or an immunocompromised state (P = 0.003) compared to those without infarction. Patients with infarctions presented with lower scores on the Glasgow Coma Scale (P < 0.001), lower CSF white cell counts (P = 0.001), and higher serum erythrocyte sedimentation rate (ESR) (P < 0.001). Unfavorable outcome occurred in 108 (62%) patients with infarctions. In a multivariate analysis, infarction was related with unfavorable outcome (odds ratio 3.37; 95% confidence interval 2.19-5.21; P < 0.001). We identified lower CSF white cell counts and high ESR to be independent risk factors for cerebral infarction.
conclusionCerebral infarction is a common and severe complication in adults with community-acquired bacterial meningitis. Preventing cerebral infarctions will be important in reducing the high morbidity and mortality rate in adults with community-acquired bacterial meningitis.
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