ArticleDigestive diseases and sciences2012
Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses.Biogerontology · 2024Review
- Sequence of events leading to primary biliary cholangitis.World journal of gastroenterology · 2023Review
- Role of autophagy in aging: The good, the bad, and the ugly.Aging cell · 2023Review
- Autophagy in liver diseases.World journal of hepatology · 2021Review
- Biliary Epithelial Senescence in Liver Disease: There Will Be SASP.Frontiers in molecular biosciences · 2021Review
- Senescence-Induced Chemoresistance in Triple Negative Breast Cancer and Evolution-Based Treatment Strategies.Frontiers in oncology · 2021Review
- Aging-Related Molecular Pathways in Chronic Cholestatic Conditions.Frontiers in medicine · 2019Review
- [Clinical significance and correlation of ductular reaction in hepatobiliary diseases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018Article
- Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells.Cell death & disease · 2018Article
- Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations.Current rheumatology reports · 2018Review
- Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms.JCI insight · 2017Article
- The impact of autophagy on the development of senescence in primary tubular epithelial cells.Cell cycle (Georgetown, Tex.) · 2016Article
- Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments.Journal of the American Society of Nephrology : JASN · 2016Article
- Autophagy and apoptosis in liver injury.Cell cycle (Georgetown, Tex.) · 2015Review
- Transforming growth factor‑β1 reduces apoptosis via autophagy activation in hepatic stellate cells.Molecular medicine reports · 2014Article
- Autophagy in hepatic fibrosis.BioMed research international · 2014Review
- Role of p62/SQSTM1 in liver physiology and pathogenesis.Experimental biology and medicine (Maywood, N.J.) · 2013Review
- Autophagy and senescence: a partnership in search of definition.Autophagy · 2013Article
- CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.Cell cycle (Georgetown, Tex.) · 2012Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimRecent studies disclosed that autophagy facilitates the process of senescence. Given that cellular senescence is involved in the pathophysiology of ductular reaction (DR) in primary biliary cirrhosis (PBC), we examined an involvement of autophagy in DRs in PBC and control livers.
methodsWe examined immunohistochemically the expression of microtubule-associated proteins light chain 3β (LC3) as autophagy marker, p62/sequestosome-1 (p62) as autophagy-related marker in bile ductular cells in livers taken from the patients with PBC (n = 42), and control livers (n = 100). The expression of senescent markers (p16(INK4a) and p21(WAF1/Cip1)) in bile ductular cells and their correlation with autophagy was also evaluated.
resultsThe expression of LC3 was seen in coarse vesicles in the cytoplasm of bile ductular cells and significantly more frequently in PBC of both early and advanced stages when compared to control livers (p < 0.01). The expression of p62 was seen as intracytoplasmic aggregates and significantly more frequently in PBC when compared to control livers (p < 0.05). The expression of LC3 and p62 significantly correlated with each other (p < 0.01). The expression of LC3 and p62 significantly correlated with the expression of p16(INK4a), p21(WAF1/Cip1) (p < 0.05).
conclusionsAutophagy is frequently seen in bile ductular cells in DRs in PBC. Since cellular senescence of bile ductular cells is rather frequent in the advanced stage of PBC, autophagy may precede cellular senescence of bile ductular cells in DRs in PBC.
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