ArticlePsychopharmacology2012
A modified adjusting delay task to assess impulsive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HT₂A/C and 5-HT₁A receptor agonists.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Revisiting the Role of Serotonin in Attention-Deficit Hyperactivity Disorder: New Insights from Preclinical and Clinical Studies.Clinical drug investigation · 2025Review
- Contrasting effects of DOI and lisuride on impulsive decision-making in delay discounting task.Psychopharmacology · 2022Article
- Characterization of a differential reinforcement of low rates of responding task in non-deprived male and female rats: Role of Sigma-1 receptors.Neuropharmacology · 2021Article
- Methylation Patterns of theFrontiers in psychiatry · 2020Article
- Impulsive choice does not predict binge-like eating in rats.Behavioural pharmacology · 2018Article
- 5-HTPsychopharmacology · 2018Article
- Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds.Psychopharmacology · 2018Review
- Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12.Journal of neurotrauma · 2017Article
- Optimisation of cognitive performance in rodent operant (touchscreen) testing: Evaluation and effects of reinforcer strength.Learning & behavior · 2017Article
- Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HTPsychopharmacology · 2017Article
- Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure.Psychopharmacology · 2017Article
- Can We Selectively Reduce Appetite for Energy-Dense Foods? An Overview of Pharmacological Strategies for Modification of Food Preference Behavior.Current neuropharmacology · 2016Review
- Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.British journal of pharmacology · 2014Review
- High trait impulsivity predicts food addiction-like behavior in the rat.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Role of medial prefrontal and orbitofrontal monoamine transporters and receptors in performance in an adjusting delay discounting procedure.Brain research · 2014Article
- Opioid system in the medial prefrontal cortex mediates binge-like eating.Addiction biology · 2014Article
- The uncompetitive NMDA receptor antagonists ketamine and memantine preferentially increase the choice for a small, immediate reward in low-impulsive rats.Psychopharmacology · 2013Article
- Antagonism of sigma-1 receptors blocks compulsive-like eating.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats.Behavioural pharmacology · 2012Article
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6 authors.
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Abstract
rationaleExisting animal models of impulsivity frequently use food restriction to increase subjects' motivation. In addition, behavioral tasks that assess impulsive choice typically involve the use of reinforcers with dissimilar caloric content. These factors represent energy-homeostasis limitations, which may confound the interpretation of results and limit the applicability of these models.
objectivesThis study was aimed at validating face and convergent validities of a modified adjusting delay task, which assesses impulsive choice between isocaloric reinforcers in ad libitum fed rats.
methodsMale Wistar rats (n = 18) were used to assess the preferredness and reinforcing efficacy of a "supersaccharin" solution (1.5% glucose/0.4% saccharin) over a 1.5% glucose solution. A separate group of rats (n = 24) was trained in a modified adjusting delay task, which involved repeated choice between the glucose solution delivered immediately and the supersaccharin solution delivered after a variable delay. To pharmacologically validate the task, the effects of the 5-HT(2A/C) receptor agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(±)-DOI] and the 5-HT(1A) receptor agonist (±)-8-hydroxy-2-(dipropylamino)tetralin hydrobromide [(±)-8-OH-DPAT] on impulsive choice were then evaluated.
resultsSupersaccharin was highly reinforcing and uniformly preferred over the glucose solution by all subjects. Rats quickly learned the task, and impulsivity was a very stable and consistent trait. DOI and 8-OH-DPAT significantly and dose dependently increased impulsive choice in this modified adjusting delay task.
conclusionsWe validated a rodent task of impulsive choice, which eliminates typical energy-homeostasis limitations and, therefore, opens new avenues in the study of impulsivity in preclinical feeding and obesity research.
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