Evidence map›Paper›PMID 21989667›Full record

ArticleAnnals of surgical oncology2012

Significance of metastatic lymph node ratio on stimulated thyroglobulin levels in papillary thyroid carcinoma after prophylactic unilateral central neck dissection.

Brian Hung-Hin Lang, Kai Pun Wong, Koon Yat Wan, Chung-Yau Lo

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02408887 (Randomized Controlled Trial of Total Thyroidectomy With and Without Prophylactic Central Neck Lymph Node Dissection in Patients With Low-risk Papillary Thyroid Cancer), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02408887 phase2terminatednot on this mapstarted 2015, after this paper: background citation

Randomized Controlled Trial of Total Thyroidectomy With and Without Prophylactic Central Neck Lymph Node Dissection in Patients With Low-risk Papillary Thyroid Cancer

TypeinterventionalSponsorNational Cancer Institute (NCI)Ran2015 to 2019Enrolled14ConditionsLow-risk Papillary Thyroid Cancer, Endocrine Malignancy, Thyroid CancerArmsTotal Thyroidectomy (TT), Prophylactic central neck lymph node dissection (pCND)
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
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  15. Review
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  17. Observational
  18. Article
  19. Impact of prophylactic central neck dissection on oncologic outcomes of papillary thyroid carcinoma: a review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Brian Hung-Hin LangDepartment of Surgery, The University of Hong Kong, Hong Kong, Hong Kong SAR, China. blang@hku.hk
Kai Pun Wong
Koon Yat Wan
Chung-Yau Lo
University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrognostic significance of metastatic central lymph node ratio (CLNR) in papillary thyroid carcinoma (PTC) remains unknown. Because postsurgical detectable stimulated thyroglobulin (DsTg) after radioiodine ablation may imply persistent or recurrent disease, we evaluated the association between CLNR and rate of DsTg in patients with PTC who underwent unilateral prophylactic central neck dissection.

methodsTo be eligible for analysis, the prophylactic central neck dissection specimen had to contain ≥3 central lymph nodes (CLNs) with ≥1 harboring metastasis. Of 129 specimens, 51 (39.5%) were eligible. CLNR was calculated as follows: (number of metastatic CLNs/number of CLNs retrieved)×100. They were categorized into group 1 (CLNR<33.34%) (n=14), group 2 (CLNR 33.34-66.67%) (n=15), and group 3 (CLNR>66.67%) (n=22). Postablation sTg level was measured 6 months after radioiodine ablation. A multivariate analysis was conducted to identify factors for postablation DsTg.

resultsYoung age, palpable neck swelling, large tumor size, advanced tumor, node, metastasis system (TNM) stage, and large number of metastatic CLNs were significantly associated with high CLNR (P<0.05). Compared to groups 1 and 2, group 3 had significantly higher DsTg rate (P=0.018). Those who developed subsequent recurrence had significantly higher DsTg rate than those who did not (100% vs. 39.1%, P=0.013). In the multivariate analysis for postablative DsTg, after adjusting for age, palpable neck swelling, tumor size, TNM stage, and number of metastatic CLNs, CLNR was the only independent factor (odds ratio 1.15, 95% confidence interval 1.01-1.31, P=0.036).

conclusionsA higher CLNR was associated with a higher rate of postablative DsTg; this may imply higher future recurrence rate.

Indexed as

AdolescentAdultAgedAge FactorsCarcinomaCarcinoma, PapillaryFemaleFollow-Up StudiesHumansLymphatic MetastasisLymph NodesMaleMiddle AgedMultivariate AnalysisNeck DissectionNeoplasm StagingThyroglobulin

Identifiers

PMID21989667
PMCPMC3309142
OpenAlexW2059086373

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.