ArticleCancer2012
Prevalence and predictors of interval colorectal cancers in medicare beneficiaries.
Article in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06186778 (The Impact of Repeated Colonoscopic Insert Method on the Detection Rate of Adenomas in the Sigmoid Colon), which is not on this map. Cited by 105 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Repeated Colonoscopic Insert Method on the Detection Rate of Adenomas in the Sigmoid Colon
Who cites it
105 citing papers in PubMed, 3 syntheses or guidelines pooled it, 236 citations in OpenAlex.
- Cold versus hot polypectomy/endoscopic mucosal resection-A review of current evidence.United European gastroenterology journal · 2021Pooled it
- The contribution of endoscopy quality measures to the development of interval colorectal cancers in the screening population: a systematic review.International journal of colorectal disease · 2019Pooled it
- Post-Colonoscopy Complications: A Systematic Review, Time Trends, and Meta-Analysis of Population-Based Studies.The American journal of gastroenterology · 2016Pooled it
- Clear colonoscopy as a surveillance tool in the prediction and reduction of advanced neoplasms: a randomized controlled trial.Surgical endoscopy · 2021Trial
- Impact of second forward-view examination on adenoma detection rate during unsedated colonoscopy: a randomized controlled trial.BMC gastroenterology · 2021Trial
- Trial
- Leadership training to improve adenoma detection rate in screening colonoscopy: a randomised trial.Gut · 2016Trial
- Impact of the quality of bowel cleansing on the efficacy of colonic cancer screening: a prospective, randomized, blinded study.PloS one · 2015Trial
- Impact of acetic acid chromoendoscopy on detection of serrated lesions in the proximal colon compared with white-light endoscopy.Endoscopy international open · 2026Article
- Clinical and endoscopic characteristics of colorectal sessile serrated lesion with dysplasia: a single-center cross-sectional comparative study.Journal of gastrointestinal oncology · 2025Article
- Private Equity Acquisition of Gastroenterology Practices and Colonoscopy Price and Quality.JAMA health forum · 2025Article
- Association between Endoscopist Volume and Interval Cancers after Colonoscopy: Results from the National Colorectal Cancer Screening Program in Korea.Cancer research and treatment · 2024Article
- Imaging colonic polyps in 2024.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Esophageal cancers missed at upper endoscopy in Central Norway 2004 to 2021 - A population-based study.BMC gastroenterology · 2024Article
- Usefulness of magnifying endoscopy for diagnosis of sessile serrated lesion with dysplasia or carcinoma: Large retrospective study.Endoscopy international open · 2024Article
- Type 2 diabetes mellitus and post-colonoscopy colorectal cancer: clinical and molecular characteristics and survival.Cancer causes & control : CCC · 2024Article
- Cost-Effectiveness of Liquid Biopsy for Colorectal Cancer Screening in Patients Who Are Unscreened.JAMA network open · 2023Article
- Postcolonoscopy Colorectal Cancer in a Referral Center for Colorectal Cancer: Prevalence and Risk Factors.GE Portuguese journal of gastroenterology · 2023Article
- Sessile serrated lesions with dysplasia: is it possible to nip them in the bud?Journal of gastroenterology · 2023Review
- Can endoscopic follow-up after acute diverticulitis be rationalised?Surgical endoscopy · 2023Observational
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAfter a colonoscopy that is negative for cancer, a subset of patients may be diagnosed with colorectal cancer, also termed interval cancer. The frequency and predictors have not been well studied in a population-based US cohort.
methodsThe authors used the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database to identify 57,839 patients aged ≥ 69 years who were diagnosed with colorectal cancer between 1994 and 2005 and who underwent colonoscopy within 6 months of cancer diagnosis. Colonoscopy performed between 6 and 36 months before cancer diagnosis was a proxy for interval cancer.
resultsBy using the case definition, 7.2% of patients developed interval cancers. Factors that were associated with interval cancers included proximal tumor location (distal colon: multivariable odds ratio [OR], 0.42; 95% confidence interval [CI], 0.390-0.46; rectum: OR, 0.47; 95% CI, 0.42-0.53), increased comorbidity (OR, 1.89; 95% CI, 1.68 2.14 for ≥ 3 comorbidities), a previous diagnosis of diverticulosis (OR, 6.00; 95% CI, 5.57-6.46), and prior polypectomy (OR, 1.74; 95% CI, 1.62-1.87). Risk factors at the endoscopist level included a lower polypectomy rate (OR, 0.70; 95% CI, 0.63-0.78 for the highest quartile), higher colonoscopy volume (OR, 1.27; 95% CI, 1.13-1.43), and specialty other than gastroenterology (colorectal surgery: OR, 1.45; 95% CI, 1.16-1.83; general surgery: OR, 1.42; 95% CI, 1.24-1.62; internal medicine: OR, 1.38; 95% CI, 1.17-1.63; family practice: OR, 1.16; 95% CI, 1.00-1.35).
conclusionsA significant proportion of patients developed interval colorectal cancer, particularly in the proximal colon. Contributing factors likely included both procedural and biologic factors, emphasizing the importance of meticulous examination of the mucosa.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.