ArticleBMC neuroscience2011
NeuriteQuant: an open source toolkit for high content screens of neuronal morphogenesis.
Article in BMC neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
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- Synthetic biodegradable microporous hydrogels for in vitro 3D culture of functional human bone cell networks.Nature communications · 2024Article
- From pixels to connections: exploring in vitro neuron reconstruction software for network graph generation.Communications biology · 2024Review
- ANDA: an open-source tool for automated image analysis of in vitro neuronal cells.BMC neuroscience · 2023Article
- Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids.International journal of molecular sciences · 2021Review
- Amyloid-β Impairs Dendritic Trafficking of Golgi-Like Organelles in the Early Phase Preceding Neurite Atrophy: Rescue by Mirtazapine.Frontiers in molecular neuroscience · 2021Article
- A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells.Life science alliance · 2020Article
- In vitro modeling of dendritic atrophy in Rett syndrome: determinants for phenotypic drug screening in neurodevelopmental disorders.Scientific reports · 2020Article
- E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration.Scientific reports · 2019Article
- Ginsenoside Rb1 improves leptin sensitivity in the prefrontal cortex in obese mice.CNS neuroscience & therapeutics · 2018Article
- ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule-associated proteins.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- DEFiNE: A Method for Enhancement and Quantification of Fluorescently Labeled Axons.Frontiers in neuroanatomy · 2018Article
- NeuronCyto II: An automatic and quantitative solution for crossover neural cells in high throughput screening.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2016Article
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- A label-free and high-throughput separation of neuron and glial cells using an inertial microfluidic platform.Biomicrofluidics · 2016Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundTo date, some of the most useful and physiologically relevant neuronal cell culture systems, such as high density co-cultures of astrocytes and primary hippocampal neurons, or differentiated stem cell-derived cultures, are characterized by high cell density and partially overlapping cellular structures. Efficient analytical strategies are required to enable rapid, reliable, quantitative analysis of neuronal morphology in these valuable model systems.
resultsHere we present the development and validation of a novel bioinformatics pipeline called NeuriteQuant. This tool enables fully automated morphological analysis of large-scale image data from neuronal cultures or brain sections that display a high degree of complexity and overlap of neuronal outgrowths. It also provides an efficient web-based tool to review and evaluate the analysis process. In addition to its built-in functionality, NeuriteQuant can be readily extended based on the rich toolset offered by ImageJ and its associated community of developers. As proof of concept we performed automated screens for modulators of neuronal development in cultures of primary neurons and neuronally differentiated P19 stem cells, which demonstrated specific dose-dependent effects on neuronal morphology.
conclusionsNeuriteQuant is a freely available open-source tool for the automated analysis and effective review of large-scale high-content screens. It is especially well suited to quantify the effect of experimental manipulations on physiologically relevant neuronal cultures or brain sections that display a high degree of complexity and overlap among neurites or other cellular structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.