Evidence map›Paper›PMID 21989069›Full record

ArticleBiochimica et biophysica acta2012

Gut triglyceride production.

Xiaoyue Pan, M Mahmood Hussain

Open access · greenAbstract read
In one paragraph

Article in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 103 citations in OpenAlex.

  1. Trial
  2. Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. The Interplay between the Gut and Ketogenic Diets in Health and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Sphingolipids and Cholesterol.Advances in experimental medicine and biology · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiaoyue PanDepartment of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY 11203, USA. Xiaoyue.Pan@downstate.edu
M Mahmood Hussain
SUNY Downstate Health Sciences University · US

Funding

MOLECULAR MECHANISMS OF CHYLOMICRON ASSEMBLYR01DK046900 · NIDDK · SUNY DOWNSTATE MEDICAL CENTER · PI HUSSAIN, M MAHMOOD · 2001 to 2011
$3.0M
Diurnal regulation of MTP and plasma lipidsR01DK081879 · NIDDK · SUNY DOWNSTATE MEDICAL CENTER · PI HUSSAIN, M MAHMOOD · 2009 to 2014
$2.3M
Molecular mechanisms of chylomicron assemblyR56DK046900 · NIDDK · SUNY DOWNSTATE MEDICAL CENTER · PI HUSSAIN, M MAHMOOD · 2015 to 2015
$140k
ASSEMBLY OF APOB48 CONTAINING LIPOPROTEINSR29DK046900 · NIDDK · MCP HAHNEMANN UNIVERSITY · PI HUSSAIN, M MAHMOOD · 1995 to 1999
–
NIDDK NIH HHS DK46900NIDDK NIH HHS DK-81879NIDDK NIH HHS R01 DK046900NIDDK NIH HHS R01 DK081879NIDDK NIH HHS R29 DK046900NIDDK NIH HHS R56 DK046900
6 · The paper itself

Abstract

Our knowledge of how the body absorbs triacylglycerols (TAG) from the diet and how this process is regulated has increased at a rapid rate in recent years. Dietary TAG are hydrolyzed in the intestinal lumen to free fatty acids (FFA) and monoacylglycerols (MAG), which are taken up by enterocytes from their apical side, transported to the endoplasmic reticulum (ER) and resynthesized into TAG. TAG are assembled into chylomicrons (CM) in the ER, transported to the Golgi via pre-chylomicron transport vesicles and secreted towards the basolateral side. In this review, we mainly focus on the roles of key proteins involved in uptake and intracellular transport of fatty acids, their conversion to TAG and packaging into CM. We will also discuss intracellular transport and secretion of CM. Moreover, we will bring to light few factors that regulate gut triglyceride production. Furthermore, we briefly summarize pathways involved in cholesterol absorption. This article is part of a Special Issue entitled Triglyceride Metabolism and Disease.

Indexed as

ChylomicronsLipid MetabolismAnimalsEndoplasmic ReticulumEnterocytesFatty AcidsHumansIntestinal AbsorptionIntestinal MucosaTriglyceridesChylomicronsFatty AcidsTriglycerides

Identifiers

PMID21989069
PMCPMC3319358
OpenAlexW2011846912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.