ArticleAmerican journal of physiology. Endocrinology and metabolism2012
Inverse regulation of basal lipolysis in perigonadal and mesenteric fat depots in mice.
Article in American journal of physiology. Endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- PVAT adipocyte: energizing, modulating, and structuring vascular function during normotensive and hypertensive states.American journal of physiology. Heart and circulatory physiology · 2025Review
- Male-Specific Effects of β-Carotene Supplementation on Lipid Metabolism in the Liver and Gonadal Adipose Tissue of Healthy Mice.Molecules (Basel, Switzerland) · 2025Article
- Gut microbiota in overweight and obesity: crosstalk with adipose tissue.Nature reviews. Gastroenterology & hepatology · 2024Review
- Inflammation of Mesenteric Adipose Tissue Correlates with Intestinal Injury and Disease Severity in Rats with Severe Acute Pancreatitis.Digestive diseases and sciences · 2023Article
- The Effect of a Sustained High-Fat Diet on the Metabolism of White and Brown Adipose Tissue and Its Impact on Insulin Resistance: A Selected Time Point Cross-Sectional Study.International journal of molecular sciences · 2021Article
- Sensory denervation of inguinal white fat modifies sympathetic outflow to white and brown fat in Siberian hamsters.Physiology & behavior · 2018Article
- The role of adipocyte-specific IL-6-type cytokine signaling in FFA and leptin release.Adipocyte · 2018Review
- Article
- Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells.Experimental and therapeutic medicine · 2017Article
- Reduced lipolysis response to adipose afferent reflex involved in impaired activation of adrenoceptor-cAMP-PKA-hormone sensitive lipase pathway in obesity.Scientific reports · 2016Article
- Identification of Mouse Mesenteric and Subcutaneous in vitro Adipogenic Cells.Scientific reports · 2016Article
- Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice.Scientific reports · 2015Article
- Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice.TheScientificWorldJournal · 2015Article
- Short-term HFD does not alter lipolytic function of adipocytes.Adipocyte · 2014Article
- Metabolic programming of adipose tissue structure and function in male rat offspring by prenatal undernutrition.Nutrition & metabolism · 2014Article
- Article
- The G0/G1 switch gene 2 (G0S2): regulating metabolism and beyond.Biochimica et biophysica acta · 2013Review
- Intra-abdominal fat depots represent distinct immunomodulatory microenvironments: a murine model.PloS one · 2013Article
- Depot-specific differences in adipocyte insulin sensitivity in mice are diet- and function-dependent.Adipocyte · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Given the strong link between visceral adiposity and (hepatic) insulin resistance as well as liver steatosis, it is crucial to characterize obesity-associated alterations in adipocyte function, particularly in fat depots drained to the liver. Yet these adipose tissues are not easily accessible in humans, and the most frequently studied depot in rodents is the perigonadal, which is drained systemically. In the present study, we aimed to study alterations in lipolysis between mesenteric and perigonadal adipocytes in mice. Basal free fatty acid and glycerol release was significantly lower in perigonadal compared with mesenteric adipocytes isolated from chow-fed C57BL/6J mice. However, this difference completely vanished in high-fat diet-fed mice. Consistently, protein levels of the G(0)/G(1) switch gene 2 (G0S2), which were previously found to be inversely related to basal lipolysis, were significantly lower in mesenteric compared with perigonadal fat of chow-fed mice. Similarly, perilipin was differently expressed between the two depots. In addition, adipocyte-specific overexpression of G0S2 led to significantly decreased basal lipolysis in mesenteric adipose tissue of chow-fed mice. In conclusion, lipolysis is differently regulated between perigonadal and mesenteric adipocytes, and these depot-specific differences might be explained by altered regulation of G0S2 and/or perilipin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.