SynthesisMedicine and science in sports and exercise2012
Intracrine and myotrophic roles of 5α-reductase and androgens: a review.
Synthesis in Medicine and science in sports and exercise, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Muscular responses to testosterone replacement vary by administration route: a systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2018Pooled it
- Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis.BMC medicine · 2014Pooled it
- Does creatine cause hair loss? A 12-week randomized controlled trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Dihydrotestosterone (DHT) rapidly increase after maximal aerobic exercise in healthy males: the lowering effect of phosphodiesterase's type 5 inhibitors on DHT response to exercise-related stress.Journal of endocrinological investigation · 2021Trial
- Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone.American journal of physiology. Endocrinology and metabolism · 2014Trial
- Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial.American journal of physiology. Endocrinology and metabolism · 2014Trial
- The impact of preoperative 5-alpha reductase inhibitors on functional outcomes and health-related quality of life following radical prostatectomy - A propensity score matched longitudinal study.World journal of urology · 2024Article
- An intracrine view of sex steroids, immunity, and metabolic regulation.Molecular metabolism · 2018Review
- Activity-Based Physical Rehabilitation with Adjuvant Testosterone to Promote Neuromuscular Recovery after Spinal Cord Injury.International journal of molecular sciences · 2018Review
- Article
- Androgen interacts with exercise through the mTOR pathway to induce skeletal muscle hypertrophy.Biology of sport · 2017Article
- Testosterone Plus Finasteride Prevents Bone Loss without Prostate Growth in a Rodent Spinal Cord Injury Model.Journal of neurotrauma · 2017Article
- Sport and male sexuality.Journal of endocrinological investigation · 2017Review
- High Prevalence of Low Serum Biologically Active Testosterone in Older Male Veterans.Journal of the American Medical Directors Association · 2017Article
- Testosterone and Adult Male Bone: Actions Independent of 5α-Reductase and Aromatase.Exercise and sport sciences reviews · 2015Review
- Injection of testosterone may be safer and more effective than transdermal administration for combating loss of muscle and bone in older men.American journal of physiology. Endocrinology and metabolism · 2015Review
- Review of health risks of low testosterone and testosterone administration.World journal of clinical cases · 2015Review
- Transcriptional regulation of myotrophic actions by testosterone and trenbolone on androgen-responsive muscle.Steroids · 2014Article
- Testosterone dose dependently prevents bone and muscle loss in rodents after spinal cord injury.Journal of neurotrauma · 2014Article
- Testosterone responses to standardized short-term sub-maximal and maximal endurance exercises: issues on the dynamic adaptive role of the hypothalamic-pituitary-testicular axis.Journal of endocrinological investigation · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledHistorically, the circulation was thought to be the primary source of androgens influencing skeletal muscle. However, a growing body of research indicates that skeletal muscle expresses several androgen-synthesizing enzymes, including 5α-reductase. The intramuscular expression of these enzymes suggests that skeletal muscle is capable of synthesizing bioactive androgens, which could induce myotrophic effects via intracrine action. PURPOSE: The aim of this brief review is to discuss recent research related to the intracrine and myotrophic roles of androgens, with particular focus on 5α-reductase as a myotrophic mediator.
methodsIncluded in the review are 17 reviews and 58 original studies that were identified by a systematic review from MEDLINE and deemed particularly relevant to our purpose. Results are summarized to provide an overview of 5α-reductase as a mediator of the myotrophic effects of androgens. In particular, discussions are included regarding androgen biosynthesis and androgen signaling within skeletal muscle, the effects of exercise on intramuscular androgen biosynthesis, and clinical applications of androgens and of a new class of myotrophic agonists termed selective androgen receptor modulator.
resultsThe ability of several peripheral tissues to synthesize bioactive androgens is well documented in the literature. Herein, we summarize newer studies that demonstrate that 1) skeletal muscle has the capability to synthesize both testosterone and dihydrotestosterone from dehydroepiandrosterone, which is present in abundance within the circulation, and 2) that exercise increases the expression of certain androgen-biosynthesizing enzymes within muscle.
conclusionsIntramuscularly synthesized androgens have the potential to influence skeletal muscle via intracrine action; however, their exact role in skeletal muscle development and maintenance requires further elucidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.