ArticleBMC neuroscience2011
Inner ear dysfunction in caspase-3 deficient mice.
Article in BMC neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- CSF1R+ macrophage and osteoclast depletion impairs neural crest proliferation and craniofacial morphogenesis.Development (Cambridge, England) · 2026Article
- Three decades of caspases and RIPKs in life and death.Human molecular genetics · 2025Review
- An open-source tool for automated human-level circling behavior detection.Scientific reports · 2024Article
- Exploring caspase functions in mouse models.Apoptosis : an international journal on programmed cell death · 2024Review
- An Open-Source Tool for Automated Human-Level Circling Behavior Detection.bioRxiv : the preprint server for biology · 2023Article
- Apoptotic cell death in disease-Current understanding of the NCCD 2023.Cell death and differentiation · 2023Review
- A review of the auditory-gut-brain axis.Frontiers in neuroscience · 2023Review
- Making the head: Caspases in life and death.Frontiers in cell and developmental biology · 2022Review
- Programmed Cell Death Recruits Macrophages Into the Developing Mouse Cochlea.Frontiers in cell and developmental biology · 2021Article
- Auditory function analysis in immunodeficient STAT1 knock-out mice: Considerations for viral infection models.Neuroscience letters · 2021Article
- Modifications to a common phosphorylation network provide individualized control in caspases.The Journal of biological chemistry · 2018Article
- What Goes Around Can Come Around: An Unexpected Deleterious Effect of Using Mouse Running Wheels for Environmental Enrichment.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish.Protein science : a publication of the Protein Society · 2016Article
- Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The role of GABAB receptors in the vestibular oculomotor system in mice.Behavioural brain research · 2016Article
- Caspases and osteogenic markers--in vitro screening of inhibition impact.In vitro cellular & developmental biology. Animal · 2016Article
- Neurosensory Differentiation and Innervation Patterning in the Human Fetal Vestibular End Organs between the Gestational Weeks 8-12.Frontiers in neuroanatomy · 2016Article
- Preserved otolith organ function in caspase-3-deficient mice with impaired horizontal semicircular canal function.Experimental brain research · 2015Article
- Dynamic characteristics of otolith ocular response during counter rotation about dual yaw axes in mice.Neuroscience · 2015Article
- Identification of I411K, a novel missense EYA4 mutation causing autosomal dominant non‑syndromic hearing loss.International journal of molecular medicine · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCaspase-3 is one of the most downstream enzymes activated in the apoptotic pathway. In caspase-3 deficient mice, loss of cochlear hair cells and spiral ganglion cells coincide closely with hearing loss. In contrast with the auditory system, details of the vestibular phenotype have not been characterized. Here we report the vestibular phenotype and inner ear anatomy in the caspase-3 deficient (Casp3(-/-)) mouse strain.
resultsAverage ABR thresholds of Casp3(-/-) mice were significantly elevated (P < 0.05) compared to Casp3(+/-) mice and Casp3(+/+) mice at 3 months of age. In DPOAE testing, distortion product 2F1-F2 was significantly decreased (P < 0.05) in Casp3(-/-) mice, whereas Casp3(+/-) and Casp3(+/+) mice showed normal and comparable values to each other. Casp3(-/-) mice were hyperactive and exhibited circling behavior when excited. In lateral canal VOR testing, Casp3(-/-) mice had minimal response to any of the stimuli tested, whereas Casp3(+/-) mice had an intermediate response compared to Casp3(+/+) mice. Inner ear anatomical and histological analysis revealed gross hypomorphism of the vestibular organs, in which the main site was the anterior semicircular canal. Hair cell numbers in the anterior- and lateral crista, and utricle were significantly smaller in Casp3(-/-) mice whereas the Casp3(+/-) and Casp3(+/+) mice had normal hair cell numbers.
conclusionsThese results indicate that caspase-3 is essential for correct functioning of the cochlea as well as normal development and function of the vestibule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.