ArticleThe Plant journal : for cell and molecular biology2012
Accelerated cell death 2 suppresses mitochondrial oxidative bursts and modulates cell death in Arabidopsis.
Article in The Plant journal : for cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Singlet Oxygen in Plants: Mechanistic Insights into Production, Oxidative Damage, and Stress-Response Signaling.Antioxidants (Basel, Switzerland) · 2026Review
- Oxidative stress inFrontiers in plant science · 2026Review
- Investigating the mechanism of chloroplast singlet oxygen signaling in thePlant signaling & behavior · 2024Article
- γ-Aminobutyric Acid Alleviates Programmed Cell Death in TwoInternational journal of molecular sciences · 2024Article
- Singlet Oxygen and Superoxide Anion Radical Detection by EPR Spin Trapping in Thylakoid Preparations.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Singlet Oxygen Detection by Chemiluminescence Probes in Living Cells.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs.Plant physiology · 2023Article
- (±)-3-Deoxyradicinin Induces Stomata Opening and Chloroplast Oxidative Stress in Tomato (International journal of molecular sciences · 2023Article
- Fine Mapping and Candidate Gene Analysis ofFrontiers in plant science · 2022Article
- Rice Lesion Mimic Mutants (LMM): The Current Understanding of Genetic Mutations in the Failure of ROS Scavenging during Lesion Formation.Plants (Basel, Switzerland) · 2021Review
- Series-Spatial Transcriptome Profiling of Leafy Head Reveals the Key Transition Leaves for Head Formation in Chinese Cabbage.Frontiers in plant science · 2021Article
- Singlet Oxygen in Plants: Generation, Detection, and Signaling Roles.International journal of molecular sciences · 2020Review
- A role for Arabidopsis growth-regulating factors 1 and 3 in growth-stress antagonism.Journal of experimental botany · 2020Article
- Deficiencies in the Mitochondrial Electron Transport Chain Affect Redox Poise and Resistance TowardFrontiers in plant science · 2019Article
- PROHIBITIN3 Forms Complexes with ISOCHORISMATE SYNTHASE1 to Regulate Stress-Induced Salicylic Acid Biosynthesis in Arabidopsis.Plant physiology · 2018Article
- Convergence of mitochondrial and chloroplastic ANAC017/PAP-dependent retrograde signalling pathways and suppression of programmed cell death.Cell death and differentiation · 2017Review
- The Roles of Mitochondrial Reactive Oxygen Species in Cellular Signaling and Stress Response in Plants.Plant physiology · 2016Review
- Intracellular Redox Compartmentation and ROS-Related Communication in Regulation and Signaling.Plant physiology · 2016Review
- Identification of miRNAs and Their Targets in the Liverwort Marchantia polymorpha by Integrating RNA-Seq and Degradome Analyses.Plant & cell physiology · 2016Article
- To die or not to die? Lessons from lesion mimic mutants.Frontiers in plant science · 2015Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
The Arabidopsis ACCELERATED CELL DEATH 2 (ACD2) protein protects cells from programmed cell death (PCD) caused by endogenous porphyrin-related molecules like red chlorophyll catabolite or exogenous protoporphyrin IX. We previously found that during bacterial infection, ACD2, a chlorophyll breakdown enzyme, localizes to both chloroplasts and mitochondria in leaves. Additionally, acd2 cells show mitochondrial dysfunction. In plants with acd2 and ACD2 (+) sectors, ACD2 functions cell autonomously, implicating a pro-death ACD2 substrate as being cell non-autonomous in promoting the spread of PCD. ACD2 targeted solely to mitochondria can reduce the accumulation of an ACD2 substrate that originates in chloroplasts, indicating that ACD2 substrate molecules are likely to be mobile within cells. Two different light-dependent reactive oxygen bursts in mitochondria play prominent and causal roles in the acd2 PCD phenotype. Finally, ACD2 can complement acd2 when targeted to mitochondria or chloroplasts, respectively, as long as it is catalytically active: the ability to bind substrate is not sufficient for ACD2 to function in vitro or in vivo. Together, the data suggest that ACD2 localizes dynamically during infection to protect cells from pro-death mobile substrate molecules, some of which may originate in chloroplasts, but have major effects on mitochondria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.