ArticleFoodborne pathogens and disease2012
Associations between multidrug resistance, plasmid content, and virulence potential among extraintestinal pathogenic and commensal Escherichia coli from humans and poultry.
Article in Foodborne pathogens and disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Are Food Animals Responsible for Transfer of Antimicrobial-Resistant Escherichia coli or Their Resistance Determinants to Human Populations? A Systematic Review.Foodborne pathogens and disease · 2018Pooled it
- Exploring the Antibacterial Properties of a Newly Isolated Microviridae Phage Against Multidrug-ResistantPathogens (Basel, Switzerland) · 2026Article
- Avian PathogenicVeterinary sciences · 2025Review
- Convergence of plasmid-driven virulence and antibiotic resistance in Escherichia coli.Nature communications · 2025Article
- Characterization of antimicrobial-resistantOpen veterinary journal · 2025Article
- Multidrug-resistant E. Coli in wastewater sources: a comparative study and identification of resistance hotspots.BMC microbiology · 2025Article
- Prevalence and Characterisation of Antimicrobial Resistance, Virulence Factors and Multilocus Sequence Typing (MLST) ofAnimals : an open access journal from MDPI · 2025Article
- Prevalence and genetic basis of extended-spectrum β-lactamase-producingFrontiers in veterinary science · 2025Article
- Biofilm Inhibition Activity of Fennel Honey, Fennel Essential Oil and Their Combination.Microorganisms · 2024Article
- Can Porphyrin-Triphenylphosphonium Conjugates Enhance the Photosensitizer Performance Toward Bacterial Strains?ACS applied bio materials · 2024Article
- Virulence Factor Genes in InvasiveMicroorganisms · 2023Article
- Whole Genome Sequencing of Avian PathogenicMicroorganisms · 2023Article
- Antimicrobial Resistance ofAntibiotics (Basel, Switzerland) · 2023Article
- Co-Occurrence ofAntibiotics (Basel, Switzerland) · 2023Article
- Comparative Genetic Characterization of PathogenicAnimals : an open access journal from MDPI · 2023Article
- Association Between UropathogenicInfection and drug resistance · 2023Article
- Characterizing the antimicrobial resistance profile ofVeterinary world · 2022Article
- Antimicrobial resistance, virulence genes, and phylogenetic characteristics of pathogenic Escherichia coli isolated from patients and swine suffering from diarrhea.BMC microbiology · 2022Article
- Occurrence, Phenotypic and Molecular Characteristics of Extended-Spectrum Beta-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2022Article
- F Plasmid Lineages in Escherichia coli ST95: Implications for Host Range, Antibiotic Resistance, and Zoonoses.mSystems · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The emergence of plasmid-mediated multidrug resistance (MDR) among enteric bacteria presents a serious challenge to the treatment of bacterial infections in humans and animals. Recent studies suggest that avian Escherichia coli commonly possess the ability to resist multiple antimicrobial agents, and might serve as reservoirs of MDR for human extraintestinal pathogenic Escherichia coli (ExPEC) and commensal E. coli populations. We determined antimicrobial susceptibility profiles for 2202 human and avian E. coli isolates, then sought for associations among resistance profile, plasmid content, virulence factor profile, and phylogenetic group. Avian-source isolates harbored greater proportions of MDR than their human counterparts, and avian ExPEC had higher proportions of MDR than did avian commensal E. coli. MDR was significantly associated with possession of the IncA/C, IncP1-α, IncF, and IncI1 plasmid types. Overall, inferred virulence potential did not correlate with drug susceptibility phenotype. However, certain virulence genes were positively associated with MDR, including ireA, ibeA, fyuA, cvaC, iss, iutA, iha, and afa. According to the total dataset, isolates segregated significantly according to host species and clinical status, thus suggesting that avian and human ExPEC and commensal E. coli represent four distinct populations with limited overlap. These findings suggest that in extraintestinal E. coli, MDR is most commonly associated with plasmids, and that these plasmids are frequently found among avian-source E. coli from poultry production systems.
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