ArticleExpert review of vaccines2011
Laser vaccine adjuvant for cutaneous immunization.
Article in Expert review of vaccines, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- A pilot clinical trial of a near-infrared laser vaccine adjuvant: safety, tolerability, and cutaneous immune cell trafficking.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Trial
- Fourth dose of microneedle array patch of SARS-CoV-2 S1 protein subunit vaccine elicits robust long-lasting humoral responses in mice.International immunopharmacology · 2024Article
- Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity.iScience · 2023Article
- Article
- Emerging adjuvants for intradermal vaccination.International journal of pharmaceutics · 2023Review
- Article
- Effective adjuvantation of nanograms of influenza vaccine and induction of cross-protective immunity by physical radiofrequency adjuvant.Scientific reports · 2022Article
- Potentiation of Recombinant NP and M1-Induced Cellular Immune Responses and Protection by Physical Radiofrequency Adjuvant.Vaccines · 2021Article
- Evaluation of the reactogenicity, adjuvanticity and antigenicity of LT(R192G) and LT(R192G/L211A) by intradermal immunization in mice.PloS one · 2019Article
- Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses.NPJ vaccines · 2019Article
- Augmentation of vaccine-induced humoral and cellular immunity by a physical radiofrequency adjuvant.Nature communications · 2018Article
- Laser Adjuvant-Assisted Peptide Vaccine Promotes Skin Mobilization of Dendritic Cells and Enhances Protective CD8Journal of virology · 2018Article
- Understanding natural herpes simplex virus immunity to inform next-generation vaccine design.Clinical & translational immunology · 2016Review
- Laser-induced capillary leakage for blood biomarker detection and vaccine delivery via the skin.Journal of biophotonics · 2016Article
- Effective and lesion-free cutaneous influenza vaccination.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Micro-fractional epidermal powder delivery for improved skin vaccination.Journal of controlled release : official journal of the Controlled Release Society · 2014Article
- A micro-sterile inflammation array as an adjuvant for influenza vaccines.Nature communications · 2014Article
- Laser vaccine adjuvants. History, progress, and potential.Human vaccines & immunotherapeutics · 2014Review
- An update on the use of laser technology in skin vaccination.Expert review of vaccines · 2013Review
- High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants.Vaccine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Simple and efficient technologies for intradermal immunization have recently been developed, making cutaneous vaccination a valid alternative for vaccine delivery. This raises an urgent need for safe and potent adjuvants suitable for cutaneous vaccination. Many traditional adjuvants like aluminum-based adjuvants may not be appropriate for boosting cutaneous immunization because they evoke strong and persistent inflammation in the skin that would potentially breach its integrity with serious consequences. Laser vaccine adjuvant is induced by brief illumination of a small area of the skin with a safe, noninvasive laser prior to intradermal injection of the vaccine into the site of illumination. It does not stimulate overt inflammation or reactogenicity in the skin and boosts immune responses via enhancing the motility of antigen-presenting cells. Laser vaccine adjuvant is convenient, safe and ideal for augmentation of cutaneous immunization and has distinct advantages over conventional adjuvants, in particular when encountering vaccine shortages during an unpredictable event.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.