Evidence map›Paper›PMID 21988240›Full record

ArticleChemical reviews2011

Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes.

T Kendall Harden, Gary L Waldo, Stephanie N Hicks, John Sondek

Abstract read
In one paragraph

Article in Chemical reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. GαCell communication and signaling : CCS · 2025
    Article
  5. Mitochondrial CaJournal of cellular physiology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Molecular regulation of PLCβ signaling.Methods in enzymology · 2023
    Review
  14. Review
  15. Click chemistry-enabled CRISPR screening reveals GSK3 as a regulator of PLD signaling.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Article
  17. Article
  18. Activation of Phospholipase C β by Gβγ and GαStructure (London, England : 1993) · 2020
    Article
  19. Uveal melanoma: progress in molecular biology and therapeutics.Therapeutic advances in medical oncology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

T Kendall HardenDepartment of Pharmacology and the Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA. tkh@med.unc.edu
Gary L Waldo
Stephanie N Hicks
John Sondek

Funding

Regulation of Phospholipase CR01GM057391 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONDEK, JOHN E · 1998 to 2021
$6.9M
NIGMS NIH HHS R01 GM057391
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Signal TransductionAnimalsBiocatalysisGTP-Binding Protein alpha Subunits, Gq-G11Guanosine TriphosphateHumansHydrolysisLipid MetabolismPhospholipase C betaProtein BindingProtein ConformationReceptors, G-Protein-CoupledGTP-Binding Protein alpha Subunits, Gq-G11Guanosine TriphosphatePhospholipase C betaReceptors, G-Protein-Coupled

Identifiers

PMID21988240
PMCPMC3626114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.