Trial reportArchives of ophthalmology (Chicago, Ill. : 1960)2012
Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT).
Trial report in Archives of ophthalmology (Chicago, Ill. : 1960), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00324168 (Steroids for Corneal Ulcers Trial), which is not on this map. Cited by 99 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Steroids for Corneal Ulcers Trial
Who cites it
99 citing papers in PubMed, 2 syntheses or guidelines pooled it, 212 citations in OpenAlex.
- Topical antibiotics for treating bacterial keratitis: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Topical corticosteroids as adjunctive therapy for bacterial keratitis.The Cochrane database of systematic reviews · 2014Pooled it
- Visual Impairment in Fungal Versus Bacterial Corneal Ulcers 4 Years After Successful Antimicrobial Treatment.American journal of ophthalmology · 2019Trial
- Effect of Oral Voriconazole on Fungal Keratitis in the Mycotic Ulcer Treatment Trial II (MUTT II): A Randomized Clinical Trial.JAMA ophthalmology · 2016Trial
- Early addition of topical corticosteroids in the treatment of bacterial keratitis.JAMA ophthalmology · 2014Trial
- Visual recovery in treated bacterial keratitis.Ophthalmology · 2014Trial
- Visual outcomes in treated bacterial keratitis: four years of prospective follow-up.Investigative ophthalmology & visual science · 2014Trial
- Cytotoxic clinical isolates of Pseudomonas aeruginosa identified during the Steroids for Corneal Ulcers Trial show elevated resistance to fluoroquinolones.BMC ophthalmology · 2014Trial
- The steroids for corneal ulcers trial (SCUT): secondary 12-month clinical outcomes of a randomized controlled trial.American journal of ophthalmology · 2014Trial
- Differences in clinical outcomes in keratitis due to fungus and bacteria.JAMA ophthalmology · 2013Trial
- The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole.JAMA ophthalmology · 2013Trial
- Fluoroquinolone treatment and susceptibility of isolates from bacterial keratitis.JAMA ophthalmology · 2013Trial
- Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis.Investigative ophthalmology & visual science · 2013Trial
- Prior elicitation and Bayesian analysis of the Steroids for Corneal Ulcers Trial.Ophthalmic epidemiology · 2012Trial
- Nocardia keratitis: clinical course and effect of corticosteroids.American journal of ophthalmology · 2012Trial
- Pseudomonas aeruginosa keratitis: outcomes and response to corticosteroid treatment.Investigative ophthalmology & visual science · 2012Trial
- Real-World Management and Patterns of Antibiotic Use in Patients with Keratitis and Ocular Surface Injuries: A Nationwide Survey Study in Spain.Antibiotics (Basel, Switzerland) · 2026Article
- A web-based semi-supervised deep learning platform for automated AS-OCT assessment and monitoring of infectious keratitis.NPJ digital medicine · 2026Article
- Latent Supervision: A Method for Improved Performance and Calibration of Machine Learning Classification Models in Ophthalmology.Ophthalmology science · 2026Article
- Novel Inositol Acyltransferase (Gwt1) Inhibitor for Fungal Keratitis Treatment: Evaluation of In Vitro and In Vivo Efficacy and Safety.Investigative ophthalmology & visual science · 2026Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether there is a benefit in clinical outcomes with the use of topical corticosteroids as adjunctive therapy in the treatment of bacterial corneal ulcers.
methodsRandomized, placebo-controlled, double-masked, multicenter clinical trial comparing prednisolone sodium phosphate, 1.0%, to placebo as adjunctive therapy for the treatment of bacterial corneal ulcers. Eligible patients had a culture-positive bacterial corneal ulcer and received topical moxifloxacin for at least 48 hours before randomization.
main outcome measuresThe primary outcome was best spectacle-corrected visual acuity (BSCVA) at 3 months from enrollment. Secondary outcomes included infiltrate/scar size, reepithelialization, and corneal perforation.
resultsBetween September 1, 2006, and February 22, 2010, 1769 patients were screened for the trial and 500 patients were enrolled. No significant difference was observed in the 3-month BSCVA (-0.009 logarithm of the minimum angle of resolution [logMAR]; 95% CI, -0.085 to 0.068; P = .82), infiltrate/scar size (P = .40), time to reepithelialization (P = .44), or corneal perforation (P > .99). A significant effect of corticosteroids was observed in subgroups of baseline BSCVA (P = .03) and ulcer location (P = .04). At 3 months, patients with vision of counting fingers or worse at baseline had 0.17 logMAR better visual acuity with corticosteroids (95% CI, -0.31 to -0.02; P = .03) compared with placebo, and patients with ulcers that were completely central at baseline had 0.20 logMAR better visual acuity with corticosteroids (-0.37 to -0.04; P = .02).
conclusionsWe found no overall difference in 3-month BSCVA and no safety concerns with adjunctive corticosteroid therapy for bacterial corneal ulcers. APPLICATION TO CLINICAL PRACTICE: Adjunctive topical corticosteroid use does not improve 3-month vision in patients with bacterial corneal ulcers.
trial registrationclinicaltrials.gov Identifier: NCT00324168.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.