ArticleToxicological sciences : an official journal of the Society of Toxicology2012
PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 31 citations in OpenAlex.
- A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism.Molecular brain · 2022Article
- Predicting the in vivo developmental toxicity of benzo[a]pyrene (BaP) in rats by an in vitro-in silico approach.Archives of toxicology · 2021Article
- Air pollution and children's health-a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter.Environmental health and preventive medicine · 2021Review
- Adolescence benzo[a]pyrene treatment induces learning and memory impairment and anxiolytic like behavioral response altering neuronal morphology of hippocampus in adult male Wistar rats.Toxicology reports · 2019Article
- Revealing Behavioral Learning Deficit Phenotypes Subsequent to In Utero Exposure to Benzo(a)pyrene.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Application of Citizen Science Risk Communication Tools in a Vulnerable Urban Community.International journal of environmental research and public health · 2015Article
- Effects of prenatal exposure to air pollutants (polycyclic aromatic hydrocarbons) on the development of brain white matter, cognition, and behavior in later childhood.JAMA psychiatry · 2015Article
- Neurological effects of inorganic arsenic exposure: altered cysteine/glutamate transport, NMDA expression and spatial memory impairment.Frontiers in cellular neuroscience · 2015Article
- Effects on specific promoter DNA methylation in zebrafish embryos and larvae following benzo[a]pyrene exposure.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2014Article
- Molecular and neurodevelopmental benefits to children of closure of a coal burning power plant in China.PloS one · 2014Article
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12 authors at 4 institutions in 2 countries.
Funding
Abstract
The wild-type (WT) Cpr(lox/lox) (cytochrome P(450) oxidoreductase, Cpr) mouse is an ideal model to assess the contribution of P(450) enzymes to the metabolic activation and disposition of environmental xenobiotics. In the present study, we examined the effect of in utero exposure to benzo(a)pyrene [B(a)P] aerosol on Sp4 and N-methyl-D-aspartate (NMDA)-dependent systems as well as a resulting behavioral phenotype (object discrimination) in Cpr offspring. Results from in utero exposure of WT Cpr(lox/lox) mice were compared with in utero exposed brain-Cpr-null offspring mice. Null mice were used as they do not express brain cytochrome P(450)1B1-associated NADPH oxidoreductase (CYP1B1-associated NADPH oxidoreductase), thus reducing their capacity to produce neural B(a)P metabolites. Subsequent to in utero (E14-E17) exposure to B(a)P (100 μg/m(3)), Cpr(lox/lox) offspring exhibited: (1) elevated B(a)P metabolite and F(2)-isoprostane neocortical tissue burdens, (2) elevated concentrations of cortical glutamate, (3) premature developmental expression of Sp4, (4) decreased subunit ratios of NR2B:NR2A, and (5) deficits in a novelty discrimination phenotype monitored to in utero exposed brain-Cpr-null offspring. Collectively, these findings suggest that in situ generation of metabolites by CYP1B1-associated NADPH oxidoreductase promotes negative effects on NMDA-mediated signaling processes during the period when synapses are first forming as well as effects on a subsequent behavioral phenotype.
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