ArticleGenome biology and evolution2011
Nonrandom gene loss from the Drosophila miranda neo-Y chromosome.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- Sex Chromosome Evolution: Hallmarks and Question Marks.Molecular biology and evolution · 2024Review
- The rate of W chromosome degeneration across multiple avian neo-sex chromosomes.Scientific reports · 2024Article
- Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation.PLoS biology · 2024Article
- Slower-X: reduced efficiency of selection in the early stages of X chromosome evolution.Evolution letters · 2023Article
- Schistosome W-Linked Genes Inform Temporal Dynamics of Sex Chromosome Evolution and Suggest Candidate for Sex Determination.Molecular biology and evolution · 2021Article
- Shared evolutionary trajectories of three independent neo-sex chromosomes inGenome research · 2021Article
- Article
- The timing of genetic degeneration of sex chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Gene-Level, but Not Chromosome-Wide, Divergence between a Very Young House Fly Proto-Y Chromosome and Its Homologous Proto-X Chromosome.Molecular biology and evolution · 2021Article
- Sequence analysis inGenome research · 2020Article
- The Y Chromosome as a Battleground for Intragenomic Conflict.Trends in genetics : TIG · 2020Review
- Sex Chromosome Evolution in Muscid Flies.G3 (Bethesda, Md.) · 2020Article
- Differential Gene Expression between Fungal Mating Types Is Associated with Sequence Degeneration.Genome biology and evolution · 2020Article
- Ancestral male recombination in Drosophila albomicans produced geographically restricted neo-Y chromosome haplotypes varying in age and onset of decay.PLoS genetics · 2019Article
- Gene-by-Gene or Localized Dosage Compensation on the Neo-X Chromosome in Drosophila miranda.Genome biology and evolution · 2018Article
- Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution.Genome research · 2018Article
- Convergent evolution of Y chromosome gene content in flies.Nature communications · 2017Article
- Effects of different kinds of essentiality on sequence evolution of human testis proteins.Scientific reports · 2017Article
- Avian W and mammalian Y chromosomes convergently retained dosage-sensitive regulators.Nature genetics · 2017Article
- Convergence and divergence in sex-chromosome evolution.Nature genetics · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A lack of recombination leads to the degeneration of an evolving Y chromosome. However, it is not known whether gene loss is largely a random process and primarily driven by the order in which mutations occur or whether certain categories of genes are lost less quickly than others; the latter would imply that selection counteracts the degeneration of Y chromosomes to some extent. In this study, we investigate the relationship between putative ancestral expression levels of neo-Y-linked genes in Drosophila miranda and their rates of degeneration. We use RNA-Seq data from its close relative Drosophila pseudoobscura to show that genes that have become nonfunctional on the D. miranda neo-Y had, on average, lower ancestral transcript levels and were expressed in fewer tissues compared with genes with intact reading frames. We also show that genes with male-biased expression are retained for longer on the neo-Y compared with female-biased genes. Our results imply that gene loss on the neo-Y is not a purely random, mutation-driven process. Instead, selection is--at least to some extent--preserving the function of genes that are more costly to lose, despite the strongly reduced efficacy of selection on the neo-Y chromosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.