ArticleArthritis and rheumatism2012
Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis.
Article in Arthritis and rheumatism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis.Nature communications · 2026Article
- T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis.Nature communications · 2020Article
- The eye in spondyloarthritisSeminars in arthritis and rheumatism · 2019Review
- Can nano-hydroxyapatite permeate the oral mucosa? A histological study using three-dimensional tissue models.PloS one · 2019Article
- The microbiome and HLA-B27-associated acute anterior uveitis.Nature reviews. Rheumatology · 2018Review
- The Eyes Have it: A Rheumatologist's View of Uveitis.Arthritis & rheumatology (Hoboken, N.J.) · 2018Review
- Investigation of the relationship between the onset of arthritis and uveitis in genetically predisposed SKG mice.Arthritis research & therapy · 2015Article
- Uveitis in spondyloarthritis including psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease.Clinical rheumatology · 2015Review
- All-Trans Retinoic Acid Improves the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on the Treatment of Ankylosing Spondylitis: An In Vitro Study.Stem cells international · 2015Article
- Blau syndrome-associated Nod2 mutation alters expression of full-length NOD2 and limits responses to muramyl dipeptide in knock-in mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Uveitis in seronegative arthritis.Current rheumatology reports · 2012Review
- Spondyloarthritis: the eyes have it: uveitis in patients with spondyloarthritis.Nature reviews. Rheumatology · 2012Article
- Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis.Arthritis research & therapy · 2012Article
- Why HLA-B27? My thirty-year quest: the Friedenwald lecture.Investigative ophthalmology & visual science · 2011Article
- Aberrant interleukin-1 signalling does not increase susceptibility of mice to NOD2-dependent uveitis.Clinical & experimental ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe spondylarthritides (such as ankylosing spondylitis) are multisystem inflammatory diseases that frequently result in uveitis. Despite the common co-occurrence of uveitis with arthritis, there has been no explanation for the susceptibility of the eye to inflammation. Using an innovative intravital videomicroscopic approach, we discovered the coexistence of uveitis with axial and peripheral joint inflammation in mice immunized with cartilage proteoglycan (PG). The aim of this study was to elucidate the characteristics of uveitis and test the impact of interferon-γ (IFNγ) deficiency on the eye versus the joint and spine.
methodsFemale T cell receptor (TCR)-transgenic mice or IFNγ-knockout mice crossed to TCR-transgenic mice were immunized with PG. Uveitis was assessed by intravital videomicroscopy and histology. The clinical and histopathologic severity of arthritis and spondylitis were evaluated. The bone remodeling process within the spine was assessed by whole-body near-infrared imaging. Immunoblotting and immunofluorescence staining were used to examine the expression of PG and ADAMTS-5 and to examine the cellular composition of eyes with uveitis.
resultsPG neoepitopes along with the aggrecanase ADAMTS-5 were present in the eye, as they were the joint. Anterior uveitis developed in response to PG immunization. The cellular infiltrate consisted mainly of neutrophils and eosinophils. Unexpectedly, IFNγ deficiency markedly exacerbated uveitis while ameliorating joint and spine disease, indicating divergent mechanisms that drive diseases in the eye versus the joints and spine.
conclusionThis study provides the first detailed description of a murine disease model in which uveitis coincides with arthritis and spondylitis. Our observations provide a great opportunity for understanding the pathogenesis of a relatively common but poorly understood disease.
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