ArticleCancer causes & control : CCC2011
Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia.
Article in Cancer causes & control : CCC, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00015587 (Chemical Exposures and Leukemia Risks and Childhood Leukemia and Environmental Exposure), which is not on this map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chemical Exposures and Leukemia Risks and Childhood Leukemia and Environmental Exposure
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Association of DNA repair genes polymorphisms with childhood acute lymphoblastic leukemia: a high-resolution melting analysis.BMC research notes · 2022Article
- Acute lymphoid leukemia etiopathogenesis.Molecular biology reports · 2021Review
- XRCC4 rs28360071 intronic variant is associated with increased risk for infant acute lymphoblastic leukemia with KMT2A rearrangements.Genetics and molecular biology · 2020Article
- Association betweenRadiology and oncology · 2017Article
- Childhood leukemia incidence in California: High and rising in the Hispanic population.Cancer · 2016Article
- Children's Cancer and Environmental Exposures: Professional Attitudes and Practices.Journal of pediatric hematology/oncology · 2015Article
- Genetic susceptibility in childhood acute leukaemias: a systematic review.Ecancermedicalscience · 2015Review
- The role of ATP-binding cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance.Iranian journal of pediatric hematology and oncology · 2014Review
- XRCC1 Arg399Gln variation and leukemia susceptibility: evidence from 2,647 cases and 5,518 controls.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- NBN Gene Polymorphisms and Cancer Susceptibility: A Systemic Review.Current genomics · 2013Article
- Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics.Cancer causes & control : CCC · 2013Article
- The Childhood Leukemia International Consortium.Cancer epidemiology · 2013Article
- Current evidence for an inherited genetic basis of childhood acute lymphoblastic leukemia.International journal of hematology · 2013Review
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundAcute leukemias of childhood are a heterogeneous group of malignancies characterized by cytogenetic abnormalities, such as translocations and changes in ploidy. These abnormalities may be influenced by altered DNA repair and cell cycle control processes.
methodsWe examined the association between childhood acute lymphoblastic leukemia (ALL) and 32 genes in DNA repair and cell cycle pathways using a haplotype-based approach, among 377 childhood ALL cases and 448 controls enrolled during 1995-2002.
resultsWe found that haplotypes in APEX1, BRCA2, ERCC2, and RAD51 were significantly associated with total ALL, while haplotypes in NBN and XRCC4, and CDKN2A were associated with structural and numerical change subtypes, respectively. In addition, we observed statistically significant interaction between exposure to 3 or more diagnostic X-rays and haplotypes of XRCC4 on risk of structural abnormality-positive childhood ALL.
conclusionsThese results support a role of altered DNA repair and cell cycle processes in the risk of childhood ALL, and show that this genetic susceptibility can differ by cytogenetic subtype and may be modified by exposure to ionizing radiation. To our knowledge, our study is the first to broadly examine the DNA repair and cell cycle pathways using a haplotype approach in conjunction with X-ray exposures in childhood ALL risk. If confirmed, future studies are needed to identify specific functional SNPs in the regions of interest identified in this analysis.
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Registered trials
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