ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2012
Health-related quality of life changes associated with buprenorphine treatment for opioid dependence.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Changes in Quality of Life following Buprenorphine Treatment: Relationship with Treatment Retention and Illicit Opioid Use.Journal of psychoactive drugsTrial
- External Validation of Epic's Risk of Opioid Abuse and Overdose Model Among Primary Care Patients in Three Health Systems.Journal of general internal medicine · 2026Article
- Article
- Predicting buprenorphine adherence among patients with opioid use disorder in primary care settings.BMC primary care · 2024Article
- Barriers and Facilitators to Using a Clinical Decision Support Tool for Opioid Use Disorder in Primary Care.Journal of the American Board of Family Medicine : JABFM · 2024Article
- Patient Feedback on a Mobile Medication Adherence App for Buprenorphine and Naloxone: Closed and Open-Ended Survey on Feasibility and Acceptability.JMIR formative research · 2023Article
- A Prospective Three-Months Naturalistic Follow-Up Study of Outcomes of Patients with Opioid Dependence Discharged on Buprenorphine or Oral Naltrexone.Indian journal of psychological medicine · 2023Article
- Longitudinal assessment of mental health and well-being in patients being treated with medications for opioid use disorder in primary care.Addictive behaviors reports · 2021Article
- National Survey of US HIV Clinicians: Knowledge and Attitudes About the Affordable Care Act and Opinions of its Impact on Quality of Care and Barriers to Care.Open forum infectious diseases · 2020Article
- Patient's early satisfaction with care: a predictor of health-related quality of life change among outpatients with substance dependence.Health and quality of life outcomes · 2020Article
- Factors associated with health-related quality of life in a large national sample of patients receiving opioid substitution treatment in Germany: A cross-sectional study.Substance abuse treatment, prevention, and policy · 2019Article
- Safety and tolerability of sauna detoxification for the protracted withdrawal symptoms of substance abuse.The Journal of international medical research · 2018Article
- Health Related Quality of Life in Individuals Transferred from a Needle Exchange Program and Starting Opioid Agonist Treatment.Journal of addiction · 2018Article
- Predictors of early dropout in outpatient buprenorphine/naloxone treatment.The American journal on addictions · 2016Article
- Comparison and concordance of health-related quality of life tests among substance users.Health and quality of life outcomes · 2015Article
- Quality of life improved following in-patient substance use disorder treatment.Health and quality of life outcomes · 2015Article
- Management of opioid addiction with buprenorphine: French history and current management.International journal of general medicine · 2014Article
- Budgetary impact analysis of buprenorphine-naloxone combination (Suboxone®) in Spain.Health economics review · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundFew studies have described improvement in health-related quality of life (HRQOL) associated with opioid dependence treatment with buprenorphine (ODT-B).
objectiveTo evaluate HRQOL changes in domain scores, physical and mental component summaries, and health utilities (HUs) associated with ODT-B using the Short Form 36 (SF-36).
methodsWe assessed HRQOL changes in a substudy of a pharmacokinetic study that compared buprenorphine oral tablet and liquid dosage formulations over 16 weeks. Individuals, aged 18-65 years, were screened for opioid dependence. They were excluded if they would not agree to birth control or had a serious medical condition. Subjects received psychosocial counseling and weekly group therapy. The SF-36 was administered upon enrollment and at 4-week intervals. We used the SF-6D to estimate HUs. We performed intention to treat (ITT) analyses based on the last observation available for each subject. Paired t tests of each domain and HU, limited to remaining patients at each 4-week interval, were also conducted.
resultsOf 96 subjects enrolled, cumulative dropouts over time resulted in 80, 69, 59, and 44 subjects remaining at 4, 8, 12, and 16 weeks. There were no significant differences in opioid-positive urines, dropout rates, or dosage changes between formulations. In the ITT analyses, HRQOL improvements over time were bodily pain (62.1 vs. 69.1, P = 0.017), vitality (49.8 vs. 56.5, P = 0.001), mental health (59.9 vs. 66.0, P = 0.001), social function (66.4 vs. 74.7, P = 0.001), role emotional (59.4 vs. 71.9, P = 0.003), role physical (60.9 vs. 70.6, P = 0.005), and mental component summary (41.9 vs. 45.4, P<0.001). HU scores also improved (0.674 vs. 0.715, P = 0.001). Results from paired t tests, with only concurrently enrolled patients, showed similar improvements from baseline to 4, 8, 12, or 16 weeks.
conclusionBuprenorphine, accompanied with psychosocial counseling, was associated with improved HRQOL and HUs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.