ArticleEndocrine2012
Lipoprotein(a) and homocysteine as genetic risk factors for vascular and neuropathic diabetic foot in type 2 diabetes mellitus.
Article in Endocrine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Prediction of Factors Influencing the Incidence of Diabetic Foot Ulcers Using Classical Statistical and Machine Learning Approaches: A Systematic Review.International wound journal · 2026Pooled it
- Risk Factors for First-Ever Diabetes-Related Foot Ulcer: A Systematic Review and Meta-Analysis.International wound journal · 2025Pooled it
- Association between Lipid Profile and Apolipoproteins with Risk of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Trial
- Predicting the diabetic foot in patients with type 2 diabetes mellitus based on machine learning.Biomedical engineering online · 2026Article
- Article
- Prognostic value of lipoprotein(a) for cardiovascular events after lower limb revascularization in diabetic patients with chronic limb-threatening ischemia.Cardiovascular diabetology · 2025Observational
- Association between lipoprotein(a) and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysis.Diabetology & metabolic syndrome · 2025Article
- Amino acid analysis as a method of discovering biomarkers for diagnosis of diabetes and its complications.Amino acids · 2023Review
- Circulating level of homocysteine contributes to diabetic retinopathy associated with dysregulated lipid profile and impaired kidney function in patients with type 2 diabetes mellitus.Eye (London, England) · 2023Article
- Impact of microvascular complications on the outcomes of diabetic foot in type 2 diabetic patients with documented peripheral artery disease.Endocrine · 2023Article
- Association of erectile dysfunction with diabetic foot and its outcomes in type 2 diabetic men.Hormones (Athens, Greece) · 2023Article
- Article
- Association between clitoral tissue perfusion and female sexual dysfunction in healthy women of reproductive age: a pilot study.International journal of impotence research · 2020Article
- Association Between Serum 25-OH-Vitamin D and Diabetic Foot Ulcer in Patients With Type 2 Diabetes.Frontiers in nutrition · 2020Article
- Article
- Structured therapeutic education in diabetes: is it time to re-write the chapter on the prevention of diabetic complications?Endocrine · 2016Article
- The role of patient education in the prevention and management of type 2 diabetes: an overview.Endocrine · 2016Review
- Plasma Homocysteine Levels Predict the Risk of Acute Cerebral Infarction in Patients with Carotid Artery Lesions.Molecular neurobiology · 2016Article
- Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathy and peripheral artery disease represent the main pathophysiological conditions underlying diabetic foot. Several studies showed that Lipoprotein(a)-Lp(a)-and homocysteine (Hcy) can be associated with diabetic complications, but their relationship with diabetic foot is unclear. Aim of this study was to investigate whether Lp(a) and Hcy were associated with diabetic foot ulcerations, classified according to the presence of peripheral artery disease (PAD) or neuropathy. From among consecutive type 2 diabetic attending at the Diabetic Foot Clinic 27 subjects with vascular diabetic foot (VDF), 43 with neuropathic diabetic foot (NDF) and 52 controls without foot ulceration, neuropathy, and PAD were enrolled. Both Lp(a) (26.1 ± 22.7 vs. 14.9 ± 19.5 mg/dl; P = 0.003) and Hcy levels (15.4 ± 5.7 vs. 12.2 ± 5.1 μmol/l; P = 0.022) were significantly greater in the VDF group than in controls. Lp(a) levels were significantly lower in the NDF group than in controls (6.9 ± 8.1 versus 14.9 ± 19.5 mg/dl; P = 0.009), while no difference in Hcy levels was found. Multiple logistic regression analysis showed that Hcy was associated with VDF (OR: 1.11; 95% CI: 1.07-14.1; P = 0.048). Lp(a) did not enter the model, but its P-value was very near to the significant level (OR: 1.09; 95% CI: 0.99-12.05; P = 0.059). Moreover, low Lp(a) levels were associated with NDF (OR: 0.84; 95% CI: 0.21-0.96; P = 0.039). Our study has shown for the first time that high Lp(a) and Hcy levels are associated with the development of VDF, while low Lp(a) levels appear to be associated with delayed wound healing in patients with neuropathic foot ulcerations.
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