ArticleInternational journal of obesity (2005)2012
The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents.
Article in International journal of obesity (2005), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005129 (The Bogalusa Heart Study), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Bogalusa Heart Study
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children.BMC medical genetics · 2013Trial
- Processing body (P-body) and its mediators in cancer.Molecular and cellular biochemistry · 2022Review
- Breastfeeding moderates the relationship betweenObesity science & practice · 2022Article
- Relation of FTO to BOLD response to receipt and anticipated receipt of food and monetary reward, food images, and weight gain in healthy weight adolescents.Social cognitive and affective neuroscience · 2020Article
- Obesity genetics and cardiometabolic health: Potential for risk prediction.Diabetes, obesity & metabolism · 2019Review
- Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study.Pediatric obesity · 2019Article
- The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population.PloS one · 2019Article
- BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort.International journal of obesity (2005) · 2017Article
- Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.Molecular genetics and genomics : MGG · 2015Review
- Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.Circulation. Cardiovascular genetics · 2014Article
- Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort.Pediatric obesity · 2014Article
- Gene-by-age effects on BMI from birth to adulthood: the Fels Longitudinal Study.Obesity (Silver Spring, Md.) · 2014Article
- Age- and sex-dependent association between FTO rs9939609 and obesity-related traits in Chinese children and adolescents.PloS one · 2014Article
- The effects of genetic variation in FTO rs9939609 on obesity and dietary preferences in Chinese Han children and adolescents.PloS one · 2014Article
- The bigger picture of FTO: the first GWAS-identified obesity gene.Nature reviews. Endocrinology · 2014Review
- Generalization of adiposity genetic loci to US Hispanic women.Nutrition & diabetes · 2013Article
- The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study.Diabetes · 2013Article
- The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults.Indian journal of endocrinology and metabolism · 2012Article
- Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health.Nutrition & diabetes · 2012Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo investigate possible age-related changes in associations between polymorphisms in the fat mass and obesity-associated (FTO) gene and higher body mass index (BMI). DESIGN AND SUBJECTS: Multilevel mixed regression models were used to examine associations between four FTO variants and longitudinal BMI profiles in non-Hispanic white and African American children and adolescents 8-17 years of age from two different longitudinal cohort studies, the Bogalusa Heart Study (BHS) and Project HeartBeat! (PHB). In the BHS, there were 1551 examinations of 478 African Americans and 3210 examinations of 1081 non-Hispanic whites; in PHB, there were 971 examinations of 131 African Americans and 4458 examinations of 505 non-Hispanic whites.
resultsIn African Americans, no significant FTO associations with BMI were found. In non-Hispanic whites, linkage disequilibrium among all four variants made haplotype analysis superfluous, so we focused on the single-nucleotide polymorphism, rs9939609. In longitudinal multilevel models, the A/A genotype of rs9939609 was associated with higher BMI in non-Hispanic whites in both cohorts at all ages. A significant age-by-genotype interaction found only in the BHS cohort predicted that in those with the A/A genotype, BMI would be ∼0.7 kg m(-2) higher at age 8 and ∼1.6 kg m(-2) higher at age 17 than in those with A/T or T/T genotypes. The design of PHB limited follow-up of any single individual to 4 years, and may have reduced the ability to detect any age-by-genotype interaction in this cohort.
conclusionsThe A/A genotype of rs9939609 in the FTO gene is associated with higher longitudinal BMI profiles in non-Hispanic whites from two different cohorts. The association may change with age, with the A/A genotype being associated with a larger BMI difference in late adolescence than in childhood, though this was observed only in the BHS cohort and requires verification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.