ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2012
Systemic inflammation and prediction of chemotherapy outcomes in patients receiving docetaxel for advanced cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Pooled it
- Microwave ablation of hepatocellular carcinoma with portal vein tumor thrombosis after transarterial chemoembolization: a prospective study.Hepatology international · 2016Trial
- Vanillic acid ameliorates docetaxel-induced hepatotoxicity in rats via modulation of TLR4/MyD88/TRAF6, NF-κB, and JAK/STAT signaling pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Prognostic Value of Post First-Line Chemotherapy Glasgow Prognostic Score in Advanced Non-Small Cell Lung Cancer.Clinical Medicine Insights. Oncology · 2022Article
- Association of systemic inflammation with survival in patients with cancer cachexia: results from a multicentre cohort study.Journal of cachexia, sarcopenia and muscle · 2021Article
- Comparing the protective effects of resveratrol, curcumin and sulforaphane against LPS/IFN-γ-mediated inflammation in doxorubicin-treated macrophages.Scientific reports · 2021Article
- Neutrophil Heterogeneity in Cancer: From Biology to Therapies.Frontiers in immunology · 2019Review
- Prognostic value of the Glasgow Prognostic Score for glioblastoma multiforme patients treated with radiotherapy and temozolomide.Journal of neuro-oncology · 2018Article
- The Prognostic Value of Preoperative Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer.World journal of surgery · 2016Article
- Prognostic performance of inflammation-based prognostic indices in primary operable non-small cell lung cancer.British journal of cancer · 2014Article
- Inflammation as a validated prognostic determinant in carcinoma of unknown primary site.British journal of cancer · 2014Article
- The Prognostic Role of the Neutrophil-to-Lymphocyte Ratio in Oropharyngeal Carcinoma Treated with Chemoradiotherapy.Clinical Medicine Insights. Oncology · 2014Article
- An inflammation based score can optimize the selection of patients with advanced cancer considered for early phase clinical trials.PloS one · 2014Article
- Article
- The systemic inflammatory response and its relationship to pain and other symptoms in advanced cancer.The oncologist · 2013Article
- Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory markers are strong prognostic factors for survival in a variety of cancers. This study aimed to investigate the relationships between known inflammatory markers and their ability to predict overall survival (OS) in patients receiving docetaxel therapy.
methodsSixty-eight patients with advanced cancer were enrolled in a clinical trial of single agent docetaxel from 2000 to 2002. Inflammation was measured using baseline cytokine concentrations, acute phase reactant proteins and white blood cell counts. The neutrophil/lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS) were calculated. Associations between inflammatory markers and their predictive value for OS were tested.
resultsThe majority of patients had elevated inflammatory markers (50-70%). Strong inter-relationships were observed between the different inflammatory indices. Only NLR and GPS were independently predictive of OS. A combined NLR and GPS score demonstrated 11 month differences in overall OS between patients with normal and elevated inflammatory status. Normalisation of NLR after three doses of chemotherapy was associated with significant improvement in survival.
conclusionThis study found that NLR predicts the clinical outcomes for patients with advanced cancer treated with docetaxel. The clinical utilisation of NLR should be validated in a larger patient population to confirm its utility.
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