ArticleMolecules (Basel, Switzerland)2011
In vitro anti-HMPV activity of meroditerpenoids from marine alga Stypopodium zonale (Dictyotales).
Article in Molecules (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 30 citations in OpenAlex.
- In Vitro Antiviral Activity of Red Algae Extracts fromTropical medicine and infectious disease · 2026Article
- Potential of Marine Terpenoids against SARS-CoV-2: AnBiomedicines · 2021Article
- Seaweed Phenolics: From Extraction to Applications.Marine drugs · 2020Review
- Natural 6-hydroxy-chromanols and -chromenols: structural diversity, biosynthetic pathways and health implications.RSC advances · 2018Review
- The Brown Alga Stypopodium zonale (Dictyotaceae): A Potential Source of Anti-Leishmania Drugs.Marine drugs · 2016Article
- Antimicrobial Action of Compounds from Marine Seaweed.Marine drugs · 2016Review
- Antifungal and antiviral products of marine organisms.Applied microbiology and biotechnology · 2014Review
- In Vitro Virucidal and Virustatic Properties of the Crude Extract of Cynodon dactylon against Porcine Reproductive and Respiratory Syndrome Virus.Veterinary medicine international · 2014Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
In this paper, we evaluated the antiviral activity against HMPV replication of crude extract of the marine algae Stypopodium zonale and of two meroditerpenoids obtained from it, atomaric acid and epitaondiol, and a methyl ester derivative of atomaric acid. Their selectivity indexes were 20.78, >56.81, 49.26 and 12.82, respectively. Compared to ribavirin, the substances showed a relatively low cytotoxicity on LLC-MK2 cells, with a significant antiviral activity, inhibiting at least 90% of viral replication in vitro, which demonstrates the potential of these marine natural products to combat infections caused by HMPV in vitro.
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