ArticleHypertension (Dallas, Tex. : 1979)2011
Restless legs syndrome and hypertension in middle-aged women.
Article in Hypertension (Dallas, Tex. : 1979), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Smoking and risk of restless leg syndrome: a systematic review, meta-analysis, and Mendelian randomisation.Journal of global health · 2026Pooled it
- Association between restless legs syndrome and hypertension: a meta-analysis of nine population-based studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Pooled it
- Comorbidities and lifestyle changes as predictors of the multiple sclerosis prodrome: A prospective cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Restless Legs Syndrome: A Network Model of Iron-Dependent Neuromodulation-A Narrative Review.Brain sciences · 2026Review
- Restless legs syndrome and periodic limb movements of sleep - the relationship with stroke and other cerebrovascular disease.Nature reviews. Neurology · 2026Review
- Neural Correlates of Restless Legs Syndrome (RLS) Based on Electroencephalogram (EEG)-A Mechanistic Review.International journal of molecular sciences · 2025Review
- Effect of hypnosis on anxiety and blood pressure of pregnant women with preeclampsia: A double-blind controlled clinical trial study.Journal of education and health promotion · 2024Article
- Patients with a Higher Number of Periodic Limb Movements Have Higher Nocturnal Blood Pressure.Journal of clinical medicine · 2022Article
- Restless legs syndrome.Nature reviews. Disease primers · 2021Review
- Blood pressure profile and endothelial function in restless legs syndrome.Scientific reports · 2019Article
- Association between Restless Legs Syndrome Symptoms and Self-Reported Hypertension: a Nationwide Questionnaire Study in Korea.Journal of Korean medical science · 2019Article
- Higher Prevalence of Hypertension among Individuals with Restless Legs Syndrome: A Meta-Analysis.Psychiatry investigation · 2018Article
- Evaluation of Cardiovascular Risk Factors and Restless Legs Syndrome in Women and Men: A Preliminary Population-Based Study in China.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers.Journal of renal injury prevention · 2017Article
- Article
- Nocturnal systolic blood pressure is increased in restless legs syndrome.Sleep & breathing = Schlaf & Atmung · 2016Article
- Restless Legs Syndrome in Patients with Hypertension and Diabetes Mellitus.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2016Article
- Restless Legs Symptoms and Pregnancy and Neonatal Outcomes.Clinical therapeutics · 2016Article
- Predictive factors of restless leg syndrome in hemodialysis patients.Journal of renal injury prevention · 2016Article
- Lack of Association between Genetic Risk Loci for Restless Legs Syndrome and Multimorbidity.Sleep · 2016Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
Limited research suggests a relationship between restless legs syndrome and hypertension. We, therefore, assessed the relationship between restless legs syndrome and hypertension among middle-aged women. This is a cross-sectional study including 65 544 women (aged 41-58 years) participating in Nurses' Health Study II. The participants with diabetes mellitus and arthritis were excluded, because these conditions can mimic restless legs syndrome. Restless legs syndrome was assessed by a self-administered questionnaire based on the International Restless Legs Study Group criteria. Information on diagnosis of hypertension and blood pressure values were collected via questionnaires. Multivariable logistic regression models were used to analyze the relation between restless legs syndrome and hypertension, with adjustment for age, race, body mass index, physical activity, menopausal status, smoking, use of analgesics, and intake of alcohol, caffeine, folate, and iron. Compared with women with no restless legs symptoms, the multiple adjusted odds of having hypertension were 1.20 times (95% CI: 1.10-1.30; P<0.0001) higher among women with restless legs symptoms. The adjusted odds ratios for women who reported restless legs symptoms 5 to 14 times per month and ≥15 times per month were 1.06 (95% CI: 0.94-1.18) and 1.41 (95% CI: 1.24-1.61) respectively, compared with those without the symptoms (P trend: <0.0001). Greater frequency of restless legs symptoms was associated with higher concurrent systolic and diastolic blood pressures (P trend: <0.0001 for both). Women with restless legs syndrome have a higher prevalence of hypertension, and this prevalence increases with more frequent restless legs symptoms.
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