ArticleMolecular and cellular biology2011
Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Notch Signalling Plays a Role in Patterning the Ventral Mesoderm During Early Embryogenesis inInternational journal of molecular sciences · 2026Article
- Regulation of epithelial cell jamming transition by cytoskeleton and cell-cell interactions.Biophysics reviews · 2024Review
- Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the earlyeLife · 2024Article
- Overexpression of TRAF4 promotes lung cancer growth and EGFR-dependent phosphorylation of ERK5.FEBS open bio · 2022Article
- The Research Progress in Physiological and Pathological Functions of TRAF4.Frontiers in oncology · 2022Review
- Mechanical competition alters the cellular interpretation of an endogenous genetic program.The Journal of cell biology · 2021Article
- Extremely rapid and reversible optogenetic perturbation of nuclear proteins in living embryos.Developmental cell · 2021Article
- Orchestrating morphogenesis: building the body plan by cell shape changes and movements.Development (Cambridge, England) · 2020Review
- The Physical Mechanisms ofGenetics · 2020Article
- NewG3 (Bethesda, Md.) · 2019Article
- Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4.Cell adhesion & migration · 2018Article
- Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling.Nature communications · 2017Article
- From morphogen to morphogenesis and back.Nature · 2017Review
- Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies.eLife · 2016Article
- Global analysis of dorsoventral patterning in the wasp Nasonia reveals extensive incorporation of novelty in a regulatory network.BMC biology · 2016Article
- Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly.The Journal of cell biology · 2016Article
- Proliferative role of TRAF4 in breast cancer by upregulating PRMT5 nuclear expression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Expression and anti-apoptotic function of TRAF4 in human breast cancer MCF-7 cells.Oncology letters · 2014Article
- Discrete levels of Twist activity are required to direct distinct cell functions during gastrulation and somatic myogenesis.PloS one · 2014Article
- The phosphoinositide-binding protein TRAF4 modulates tight junction stability and migration of cancer cells.Tissue barriers · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apical constriction of epithelial cells is a widely used morphogenetic mechanism. In the Drosophila embryo, the apical constrictions that internalize the mesoderm are controlled by the transcription factor Twist and require intact adherens junctions and a contractile acto-myosin network. We find that adherens junctions in constricting mesodermal cells undergo extensive remodeling. A Twist target gene encoding a member of the tumor necrosis factor (TNF) receptor-associated factor (TRAF) family, Traf4, is involved in this process. While TRAFs are best known for their functions in inflammatory responses, Traf4 appears to have a different role, and its mechanism of action is poorly understood. We show that Traf4 is required for efficient apical constriction during ventral furrow formation and for proper localization of Armadillo to the apical position in constricting cells. Traf4 and Armadillo interact with each other physically and functionally. Traf4 acts in a TNF receptor- and Jun N-terminal protein kinase (JNK)-independent manner to fine-tune the assembly of adherens junctions in the invaginating mesodermal cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.