Evidence map›Paper›PMID 21986423›Full record

ReviewWorld neurosurgery

Introduction to induced pluripotent stem cells: advancing the potential for personalized medicine.

Johnathan D Ebben, Michael Zorniak, Paul A Clark, John S Kuo

Abstract readReview
In one paragraph

Review in World neurosurgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. ALIX increases protein content and protective function of iPSC-derived exosomes.Journal of molecular medicine (Berlin, Germany) · 2019
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Allogenicity & immunogenicity in regenerative stem cell therapy.The Indian journal of medical research · 2013
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Craniofacial reconstruction with induced pluripotent stem cells.The Journal of craniofacial surgery · 2012
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Johnathan D EbbenBrain Tumor Research Laboratory, Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Michael Zorniak
Paul A Clark
John S Kuo
University of Wisconsin–Madison · US

Funding

NEUROSCIENCE TRAINING PROGRAMT32GM007507 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HALLORAN, MARY C · 1985 to 2017
$9.3M
NIGMS NIH HHS GM007507NIGMS NIH HHS T32 GM007507PHS HHS T32
6 · The paper itself

Abstract

Induced pluripotent stem (iPS) cell technology has enormous potential to advance medical therapy by personalizing regenerative medicine and creating novel human disease models for research and therapeutic testing. Before this technology is broadly used in the clinic, we must realistically evaluate its disease modeling and therapeutic potential. Recent advances including the use of iPS cells to successfully model spinal muscular atrophy in vitro, as well as new techniques in generating iPS cells with recombinant proteins have accelerated the prospects of iPS cells for clinical use in regenerative therapy. This review explores the development and limitations of iPS cell technology, presents a critical comparison of iPS cells and embryonic stem cells, and discusses potential clinical applications and future research directions.

Indexed as

Induced Pluripotent Stem CellsPeripheral Blood Stem Cell TransplantationAnemia, Sickle CellAnimalsCell EngineeringDisease Models, AnimalHumansMiceNervous System DiseasesNeurosurgeryParkinson DiseasePrecision MedicineRatsRegenerative Medicine

Identifiers

PMID21986423
PMCPMC3278994
OpenAlexW1974314284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.