ArticleProceedings of the Japan Academy. Series B, Physical and biological sciences2011
Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production.
Article in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- The PI3K/AKT/mTOR pathway in scar remodeling and keloid formation: mechanisms and therapeutic perspectives.Frontiers in pharmacology · 2025Review
- Update on the Pathogenesis of Keloid Formation.JID innovations : skin science from molecules to population health · 2024Review
- Scars.Nature reviews. Disease primers · 2023Review
- P65 mediated UBR4 in exosomes derived from menstrual blood stromal cells to reduce endometrial fibrosis by regulating YAP Ubiquitination.Journal of nanobiotechnology · 2023Article
- Characterization of the skin keloid microenvironment.Cell communication and signaling : CCS · 2023Review
- NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation.Endocrine connections · 2023Article
- An updated review of the immunological mechanisms of keloid scars.Frontiers in immunology · 2023Review
- Article
- Immune-related gene expression in skin, inflamed and keloid tissue from patients with keloids.Oncology letters · 2022Article
- The Ubiquitin Proteasome System and Skin Fibrosis.Molecular diagnosis & therapy · 2021Review
- Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 (NEDD4) Gene Polymorphism Contributes to Keloid Development in Egyptian Population.Clinical, cosmetic and investigational dermatology · 2020Article
- Cartilage-like composition of keloid scar extracellular matrix suggests fibroblast mis-differentiation in disease.Matrix biology plus · 2019Article
- Ubiquitination in Scleroderma Fibrosis and Its Treatment.Frontiers in immunology · 2018Review
- PTEN and NEDD4 in Human Breast Carcinoma.Pathology oncology research : POR · 2016Article
- NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population.American journal of translational research · 2016Article
- [Therapy of hypertrophic scars and keloids].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2014Review
- Associations between keloid severity and single-nucleotide polymorphisms: importance of rs8032158 as a biomarker of keloid severity.The Journal of investigative dermatology · 2014Article
- hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3.Cancer cell international · 2014Article
- Keloid scarring: understanding the genetic basis, advances, and prospects.Archives of plastic surgery · 2012Article
- Keloid research: current status and future directions.Scars, burns & healingReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keloid represents overgrowth of granulation tissue, which is characterized by collection of atypical fibroblasts with excessive deposition of extracellular matrix components, after skin injury, but its etiology is still largely unknown. We recently performed genome-wide association study (GWAS) of keloid and identified NEDD4 to be one of candidate molecules associated with keloid susceptibility. Here we demonstrate a possible mechanism of NEDD4 involvement in keloid formation through enhancement of the proliferation and invasiveness of fibroblasts as well as upregulation of type 1 collagen expression. Activation of NEDD4 affected subcellular localization and protein stability of p27 which was implied its critical role in contact inhibition. It also induced accumulation of β-catenin in the cytoplasm and activated the TCF/β-catenin transcriptional activity. Furthermore, NEDD4 upregulated expressions of fibronectin and type 1 collagen and contributed to the excessive accumulation of extracellular matrix. Our findings provide new insights into mechanism developing keloid and can be applied for development of a novel treatment for keloid.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.