Evidence map›Paper›PMID 21985690›Full record

SynthesisAddiction (Abingdon, England)2012

Compulsive features in behavioural addictions: the case of pathological gambling.

Nady el-Guebaly, Tanya Mudry, Joseph Zohar, Hermano Tavares, Marc N Potenza

Abstract readSystematic Review
In one paragraph

Synthesis in Addiction (Abingdon, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Network analysis of DSM-5 criteria for gambling disorder: considering sex differences in a large clinical sample.European psychiatry : the journal of the Association of European Psychiatrists · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Dopamine, behavior, and addiction.Journal of biomedical science · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Nady el-GuebalyDepartment of Psychiatry, University of Calgary, Alberta, Canada. nady.el-guebaly@albertahealthservices.ca
Tanya Mudry
Joseph Zohar
Hermano Tavares
Marc N Potenza
Alberta Health Services · CASheba Medical Center · ILUniversity of Calgary · CAYale University · US

Funding

Translational Research of Cocaine, Striatum, and ImpulsivitiesP20DA027844 · NIDA · YALE UNIVERSITY · PI POTENZA, MARC N · 2010 to 2013
$3.6M
fMRI of CBT and CM for Cocaine DependenceR01DA020908 · NIDA · YALE UNIVERSITY · PI POTENZA, MARC N · 2005 to 2009
$1.7M
fMRI of Craving in Addictions: Gender DifferencesR01DA019039 · NIDA · YALE UNIVERSITY · PI POTENZA, MARC N · 2005 to 2009
$1.6M
fMRI of Stress & Self-Control in Smoking & Obesity (7 of 14)RL1AA017539 · NIAAA · YALE UNIVERSITY · PI POTENZA, MARC N · 2007 to 2011
$1.3M
N-Acetyl Cysteine plus Behavioral Therapy for Nicotine Dependent Pathological GamRC1DA028279 · NIDA · UNIVERSITY OF MINNESOTA · PI GRANT, JON E · 2009 to 2010
$950k
NIAAA NIH HHS RL1 AA017539NIDA NIH HHS P20 DA027844NIDA NIH HHS R01 DA019039NIDA NIH HHS R01 DA020908NIDA NIH HHS RC1 DA028279
6 · The paper itself

Abstract

aimsTo describe, in the context of DSM-V, how a focus on addiction and compulsion is emerging in the consideration of pathological gambling (PG).

methodsA systematic literature review of evidence for the proposed re-classification of PG as an addiction.

resultsFindings include: (i) phenomenological models of addiction highlighting a motivational shift from impulsivity to compulsivity associated with a protracted withdrawal syndrome and blurring of the ego-syntonic/ego-dystonic dichotomy; (ii) common neurotransmitter (dopamine, serotonin) contributions to PG and substance use disorders (SUDs); (iii) neuroimaging support for shared neurocircuitries between 'behavioural' and substance addictions and differences between obsessive-compulsive disorder (OCD), impulse control disorders (ICDs) and SUDs; (iv) genetic findings more closely related to endophenotypic constructs such as compulsivity and impulsivity than to psychiatric disorders; (v) psychological measures such as harm avoidance identifying a closer association between SUDs and PG than with OCD; (vi) community and pharmacotherapeutic trials data supporting a closer association between SUDs and PG than with OCD. Adapted behavioural therapies, such as exposure therapy, appear applicable to OCD, PG or SUDs, suggesting some commonalities across disorders.

conclusionsPG shares more similarities with SUDs than with OCD. Similar to the investigation of impulsivity, studies of compulsivity hold promising insights concerning the course, differential diagnosis and treatment of PG, SUDs, and OCD.

Indexed as

Behavior TherapyCompulsive BehaviorDiagnosis, DifferentialEgoGamblingGenetic Predisposition to DiseaseHumansMotivationNarcotic AntagonistsNerve NetNeurotransmitter AgentsPhenotypeSelective Serotonin Reuptake InhibitorsNarcotic AntagonistsNeurotransmitter AgentsSelective Serotonin Reuptake Inhibitors

Identifiers

PMID21985690
PMCPMC3257403
OpenAlexW1545740572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.