ArticleBMC ecology2011
Expression plasticity of Phlebotomus papatasi salivary gland genes in distinct ecotopes through the sand fly season.
Article in BMC ecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Specificity of Phlebotomus papatasi and Phlebotomus tobbi recombinant salivary proteins developed as serological surveillance tool.Parasites & vectors · 2026Article
- Species diversity and spatial distribution of CL/VL vectors: assessing bioclimatic effect on expression plasticity of genes possessing vaccine properties isolated from wild-collected sand flies in endemic areas of Iran.BMC infectious diseases · 2021Article
- Phlebotomus papatasi sand fly predicted salivary protein diversity and immune response potential based on in silico prediction in Egypt and Jordan populations.PLoS neglected tropical diseases · 2020Article
- Population genetics analysis of Phlebotomus papatasi sand flies from Egypt and Jordan based on mitochondrial cytochrome b haplotypes.Parasites & vectors · 2018Article
- Differential expression profiles of the salivary proteins SP15 and SP44 from Phlebotomus papatasi.Parasites & vectors · 2016Article
- Seasonal and Physiological Variations of Phlebotomus papatasi Salivary Gland Antigens in Central Iran.Journal of arthropod-borne diseases · 2016Article
- Impact of Insect Salivary Proteins in Blood Feeding, Host Immunity, Disease, and in the Development of Biomarkers for Vector Exposure.Current opinion in insect science · 2015Article
- Phlebotomus papatasi SP15: mRNA expression variability and amino acid sequence polymorphisms of field populations.Parasites & vectors · 2015Article
- Profiling of human acquired immunity against the salivary proteins of Phlebotomus papatasi reveals clusters of differential immunoreactivity.The American journal of tropical medicine and hygiene · 2014Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundSand fly saliva can drive the outcome of Leishmania infection in animal models, and salivary components have been postulated as vaccine candidates against leishmaniasis. In the sand fly Phlebotomus papatasi, natural sugar-sources modulate the activity of proteins involved in meal digestion, and possibly influence vectorial capacity. However, only a handful of studies have assessed the variability of salivary components in sand flies, focusing on the effects of environmental factors in natural habitats. In order to better understand such interactions, we compared the expression profiles of nine P. papatasi salivary gland genes of specimens inhabiting different ecological habitats in Egypt and Jordan and throughout the sand fly season in each habitat.
resultsThe majority of investigated genes were up-regulated in specimens from Swaymeh late in the season, when the availability of sugar sources is reduced due to water deprivation. On the other hand, these genes were not up-regulated in specimens collected from Aswan, an irrigated area less susceptible to drought effects.
conclusionExpression plasticity of genes involved with vectorial capacity in disease vectors may play an important epidemiological role in the establishment of diseases in natural habitats.
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