ArticleMitochondrial DNA2011
Extreme mitochondrial evolution in the ctenophore Mnemiopsis leidyi: Insight from mtDNA and the nuclear genome.
Article in Mitochondrial DNA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 86 citations in OpenAlex.
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- Giants among Cnidaria: Large Nuclear Genomes and Rearranged Mitochondrial Genomes in Siphonophores.Genome biology and evolution · 2024Article
- Brief History of Ctenophora.Methods in molecular biology (Clifton, N.J.) · 2024Review
- The first embryo, the origin of cancer and animal phylogeny. III. The totipotency as revealed by morphogenesis and the neoplasia controlled by cellular differentiation.Journal of biosciences · 2024Review
- Characterization of the Mitochondrial Proteome in the Ctenophore Mnemiopsis leidyi Using MitoPredictor.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Characterization of the Complete Mitochondrial Genome ofInternational journal of molecular sciences · 2023Article
- Hydrophobicity-Driven Increases in Editing in Mitochondrial mRNAs during the Evolution of Kinetoplastids.Molecular biology and evolution · 2023Article
- Confirmation of the first intronic sequence in the bivalvian mitochondrial genome ofBiology letters · 2022Article
- Multigenerational laboratory culture of pelagic ctenophores and CRISPR-Cas9 genome editing in the lobate Mnemiopsis leidyi.Nature protocols · 2022Review
- Hidden diversity of Ctenophora revealed by new mitochondrial COI primers and sequences.Molecular ecology resources · 2022Article
- Speciation of pelagic zooplankton: Invisible boundaries can drive isolation of oceanic ctenophores.Frontiers in genetics · 2022Article
- Invasion genomics uncover contrasting scenarios of genetic diversity in a widespread marine invader.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Comparative genetics of scyphozoan species reveals the geological history and contemporary processes of the Mediterranean Sea.Ecology and evolution · 2021Article
- Mitochondrial Genomic Landscape: A Portrait of the Mitochondrial Genome 40 Years after the First Complete Sequence.Life (Basel, Switzerland) · 2021Article
- Molluscan mitochondrial genomes break the rules.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Mitochondrial Genome Evolution of Placozoans: Gene Rearrangements and Repeat Expansions.Genome biology and evolution · 2021Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Recent advances in sequencing technology have led to a rapid accumulation of mitochondrial DNA (mtDNA) sequences, which now represent the wide spectrum of animal diversity. However, one animal phylum--Ctenophora--has, to date, remained completely unsampled. Ctenophores, a small group of marine animals, are of interest due to their unusual biology, controversial phylogenetic position, and devastating impact as invasive species. Using data from the Mnemiopsis leidyi genome sequencing project, we Polymerase Chain Reaction (PCR) amplified and analyzed its complete mitochondrial (mt-) genome. At just over 10 kb, the mt-genome of M. leidyi is the smallest animal mtDNA ever reported and is among the most derived. It has lost at least 25 genes, including atp6 and all tRNA genes. We show that atp6 has been relocated to the nuclear genome and has acquired introns and a mitochondrial targeting presequence, while tRNA genes have been genuinely lost, along with nuclear-encoded mt-aminoacyl tRNA synthetases. The mt-genome of M. leidyi also displays extremely high rates of sequence evolution, which likely led to the degeneration of both protein and rRNA genes. In particular, encoded rRNA molecules possess little similarity with their homologs in other organisms and have highly reduced secondary structures. At the same time, nuclear encoded mt-ribosomal proteins have undergone expansions, likely to compensate for the reductions in mt-rRNA. The unusual features identified in M. leidyi mtDNA make this organism an interesting system for the study of various aspects of mitochondrial biology, particularly protein and tRNA import and mt-ribosome structures, and add to its value as an emerging model species. Furthermore, the fast-evolving M. leidyi mtDNA should be a convenient molecular marker for species- and population-level studies.
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