ArticleAmerican journal of cancer research2011
Alternative nuclear functions for NF-κB family members.
Article in American journal of cancer research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
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Who cites it
17 citing papers in PubMed.
- Review
- Review
- Post-translational Modifications of IκBα: The State of the Art.Frontiers in cell and developmental biology · 2020Review
- Manipulation of Non-canonical NF-κB Signaling by Non-oncogenic Viruses.Archivum immunologiae et therapiae experimentalis · 2019Review
- TLR4/NF-κB axis signaling pathway-dependent up-regulation of miR-625-5p contributes to human intervertebral disc degeneration by targetingAmerican journal of translational research · 2019Article
- NF-κB Signaling in Targeting Tumor Cells by Oncolytic Viruses-Therapeutic Perspectives.Cancers · 2018Review
- NF-κB-Mediated Inflammation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Does Autophagy Play a Role?International journal of molecular sciences · 2018Review
- Screening for the Key lncRNA Targets Associated With Metastasis of Renal Clear Cell Carcinoma.Medicine · 2016Article
- Proteasome inhibition increases recruitment of IκB kinase β (IKKβ), S536P-p65, and transcription factor EGR1 to interleukin-8 (IL-8) promoter, resulting in increased IL-8 production in ovarian cancer cells.The Journal of biological chemistry · 2014Article
- Article
- Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKKα.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer.Cancer cell · 2013Article
- Expression and significance of HMGB1, TLR4 and NF-κB p65 in human epidermal tumors.BMC cancer · 2013Article
- Ubiquitination and the Ubiquitin-Proteasome System as regulators of transcription and transcription factors in epithelial mesenchymal transition of cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Review
- Regulation and function of nuclear IκBα in inflammation and cancer.American journal of clinical and experimental immunology · 2012Article
- Article
- The complex interplay between autophagy and NF-κB signaling pathways in cancer cells.American journal of cancer research · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The NF-κB signalling pathway regulates many different biological processes from the cellular level to the whole organism. The majority of these functions are completely dependent on the activation of the cytoplasmic IKK kinase complex that leads to IκB degradation and results in the nuclear translocation of specific NF-κB dimers, which, in general, act as transcription factors. Although this is a well-established mechanism of action, several publications have now demonstrated that some members of this pathway display additional functions in the nucleus as regulators of NF-κB-dependent and independent gene expression. In this review, we compiled and put in context most of the data concerning specific nuclear roles for IKK and IκB proteins.
Indexed as
Identifiers
21984965PMC3186045What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.