ArticlePloS one2011
Glucose-6-phosphate dehydrogenase protects Escherichia coli from tellurite-mediated oxidative stress.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- Despite inducing antioxidant regulation, superoxide dismutase deficiency makesFrontiers in microbiology · 2026Article
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- Antimicrobial efficacy and amino acid substitutions associated with susceptibility to the tellurium compound AS101 against Haemophilus influenzae and Haemophilus parainfluenzae.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Protein interactions in human pathogens revealed through deep learning.Nature microbiology · 2024Article
- Implications of differential peroxyl radical-induced inactivation of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase for the pentose phosphate pathway.Scientific reports · 2022Article
- Article
- Anaerobic RSH-dependent tellurite reduction contributes to Escherichia coli tolerance against tellurite.Biological research · 2022Article
- The OxyR and SoxR transcriptional regulators are involved in a broad oxidative stress response in Paraburkholderia xenovorans LB400.Biological research · 2022Article
- Fosfomycin Resistance Evolutionary Pathways ofInternational journal of molecular sciences · 2022Article
- In vitro and in silico analysis reveals antifungal activity and potential targets of curcumin on Paracoccidioides spp.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Conditional impairment of Coxiella burnetii by glucose-6P dehydrogenase activity.Pathogens and disease · 2021Article
- Article
- Diversity of the Tellurite Resistance Gene Operon inFrontiers in microbiology · 2021Article
- Effect of dithiocyano-methane on hexose monophosphate pathway in the respiratory metabolism of Escherichia coli.AMB Express · 2020Article
- Biochemical comparison of two glucose 6-phosphate dehydrogenase isozymes from a cold-adapted Pseudomonas mandelii.Extremophiles : life under extreme conditions · 2020Article
- The Inactivation of Enzymes Belonging to the Central Carbon Metabolism Is a Novel Mechanism of Developing Antibiotic Resistance.mSystems · 2020Article
- Reserve Flux Capacity in the Pentose Phosphate Pathway by NADPH Binding Is Conserved across Kingdoms.iScience · 2019Article
- Cloning, Expression, and Characterization of a Psychrophilic Glucose 6-Phosphate Dehydrogenase fromInternational journal of molecular sciences · 2019Article
- Neisseria gonorrhoeae MlaA influences gonococcal virulence and membrane vesicle production.PLoS pathogens · 2019Article
- Long-chain flavodoxin FldX1 improves Paraburkholderia xenovorans LB400 tolerance to oxidative stress caused by paraquat and H2O2.PloS one · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tellurium oxyanion tellurite induces oxidative stress in most microorganisms. In Escherichia coli, tellurite exposure results in high levels of oxidized proteins and membrane lipid peroxides, inactivation of oxidation-sensitive enzymes and reduced glutathione content. In this work, we show that tellurite-exposed E. coli exhibits transcriptional activation of the zwf gene, encoding glucose 6-phosphate dehydrogenase (G6PDH), which in turn results in augmented synthesis of reduced nicotinamide adenine dinucleotide phosphate (NADPH). Increased zwf transcription under tellurite stress results mainly from reactive oxygen species (ROS) generation and not from a depletion of cellular glutathione. In addition, the observed increase of G6PDH activity was paralleled by accumulation of glucose-6-phosphate (G6P), suggesting a metabolic flux shift toward the pentose phosphate shunt. Upon zwf overexpression, bacterial cells also show increased levels of antioxidant molecules (NADPH, GSH), better-protected oxidation-sensitive enzymes and decreased amounts of oxidized proteins and membrane lipids. These results suggest that by increasing NADPH content, G6PDH plays an important role in E. coli survival under tellurite stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.