ArticlePloS one2011
In situ distribution of HIV-binding CCR5 and C-type lectin receptors in the human endocervical mucosa.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- HIV-1 replicates and persists in vaginal epithelial dendritic cells.The Journal of clinical investigation · 2018Trial
- Article
- Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa.Nature communications · 2019Article
- Negative and Positive Selection Pressure During Sexual Transmission of Transmitted Founder HIV-1.Frontiers in immunology · 2019Review
- Loss of Intra-Epithelial Endocervical Gamma Delta (GD) 1 T Cells in HIV-Infected Women.American journal of reproductive immunology (New York, N.Y. : 1989) · 2016Article
- Progestin-Containing Contraceptives Alter Expression of Host Defense-Related Genes of the Endometrium and Cervix.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Periluminal Distribution of HIV-Binding Target Cells and Gp340 in the Oral, Cervical and Sigmoid/Rectal Mucosae: A Mapping Study.PloS one · 2015Article
- Characterization of the immune cell repertoire in the normal fallopian tube.International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2014Article
- Collection, isolation, and flow cytometric analysis of human endocervical samples.Journal of visualized experiments : JoVE · 2014Article
- Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil.Memorias do Instituto Oswaldo Cruz · 2014Article
- HIV-1 envelope replication and α4β7 utilization among newly infected subjects and their corresponding heterosexual partners.Retrovirology · 2013Article
- A systems biology examination of the human female genital tract shows compartmentalization of immune factor expression.Journal of virology · 2013Article
- Depot medroxyprogesterone acetate increases immune cell numbers and activation markers in human vaginal mucosal tissues.AIDS research and human retroviruses · 2013Article
- Innate and adaptive anti-HIV immune responses in the female reproductive tract.Journal of reproductive immunology · 2013Review
- Immunobiology of genital tract trauma: endocrine regulation of HIV acquisition in women following sexual assault or genital tract mutilation.American journal of reproductive immunology (New York, N.Y. : 1989) · 2013Review
- Review
- CCR5 expression is elevated on endocervical CD4+ T cells in healthy postmenopausal women.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Pattern Recognition Receptors in HIV Transmission.Frontiers in immunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endocervical mucosa is believed to be a primary site of HIV transmission. However, to date there is little known about the distribution of the HIV co-receptor CCR5 and the HIV-binding C-type lectin receptors, including Langerin, dendritic cell (DC)-specific intercellular adhesion molecule-grabbing non-integrin (DC-SIGN) and mannose receptor (MR) at this site. We therefore characterized the expression of these molecules in the endocervix of HIV seronegative women by computerized image analysis. Endocervical tissue biopsies were collected from women (n = 6) undergoing hysterectomy. All study individuals were diagnosed with benign and non-inflammatory diseases. CCR5+ CD4+ CD3+ T cells were found within or adjacent to the endocervical epithelium. The C-type lectin Langerin was expressed by intraepithelial CD1a+ CD4+ and CD11c+ CD4+ Langerhans cells, whereas DC-SIGN+ MR+ CD11c myeloid dendritic cells and MR+ CD68+ macrophages were localized in the submucosa of the endocervix. The previously defined immune effector cells including CD8+, CD56+, CD19+ and IgD+ cells were also found in the submucosa as well as occasional CD123+ BDCA-2+ plasmacytoid dendritic cells. Understanding the spatial distribution of potential HIV target cells and immune effector cells in relation to the endocervical canal forms a basis for deciphering the routes of HIV transmission events in humans as well as designing HIV-inhibiting compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.