ArticlePloS one2011
Neuronal activity regulates hippocampal miRNA expression.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed.
- Morin improves postoperative cognitive dysfunction by mediating the miR-138-5p/SIRT1 axis to regulate ferroptosis.Scientific reports · 2026Article
- Human cerebral spheroids undergo 4-aminopyridine-induced, activity associated changes in cellular composition and microrna expression.Scientific reports · 2022Article
- Identification of the protective effect ofPharmaceutical biology · 2021Article
- The role of the genome in experience-dependent plasticity: Extending the analogy of the genomic action potential.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Article
- MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Temporospatial guidance of activity-dependent gene expression by microRNA: mechanisms and functional implications for neural plasticity.Nucleic acids research · 2019Review
- Abnormal Expression of MicroRNAs Induced by Chronic Unpredictable Mild Stress in Rat Hippocampal Tissues.Molecular neurobiology · 2018Article
- Interplay between TETs and microRNAs in the adult brain for memory formation.Scientific reports · 2018Article
- Glial responses during epileptogenesis in Mus musculus point to potential therapeutic targets.PloS one · 2018Article
- Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017Article
- MicroRNAs: Key Regulators in the Central Nervous System and Their Implication in Neurological Diseases.International journal of molecular sciences · 2016Review
- miR-204 downregulates EphB2 in aging mouse hippocampal neurons.Aging cell · 2016Article
- Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons.Scientific reports · 2016Article
- miRNAs: biological and clinical determinants in epilepsy.Frontiers in molecular neuroscience · 2015Review
- Plasticity-related microRNA and their potential contribution to the maintenance of long-term potentiation.Frontiers in molecular neuroscience · 2015Review
- Role of MicroRNAs in innate neuroprotection mechanisms due to preconditioning of the brain.Frontiers in neuroscience · 2015Review
- Grouping Pentylenetetrazol-Induced Epileptic Rats According to Memory Impairment and MicroRNA Expression Profiles in the Hippocampus.PloS one · 2015Article
- MicroRNA-132, -134, and -138: a microRNA troika rules in neuronal dendrites.Cellular and molecular life sciences : CMLS · 2014Review
- Neuronal activity-dependent regulation of MicroRNAs.Molecules and cells · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Neuronal activity regulates a broad range of processes in the hippocampus, including the precise regulation of translation. Disruptions in proper translational control in the nervous system are associated with a variety of disorders that fall in the autistic spectrum. MicroRNA (miRNA) represent a relatively recently discovered player in the regulation of translation in the nervous system. We have conducted an in depth analysis of how neuronal activity regulates miRNA expression in the hippocampus. Using deep sequencing we exhaustively identify all miRNAs, including 15 novel miRNAs, expressed in hippocampus of the adult mouse. We identified 119 miRNAs documented in miRBase but less than half of these miRNA were expressed at a level greater than 0.1% of total miRNA. Expression profiling following induction of neuronal activity by electroconvulsive shock demonstrates that most miRNA show a biphasic pattern of expression: rapid induction of specific mature miRNA expression followed by a decline in expression. These results have important implications into how miRNAs influence activity-dependent translational control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.