ArticleThe Journal of infectious diseases2011
Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Intrahost Dynamics of Human Cytomegalovirus Variants Acquired by Seronegative Glycoprotein B Vaccinees.Journal of virology · 2019Trial
- Compartmentalized cytomegalovirus replication and transmission in the setting of maternal HIV-1 infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Trial
- Tissue-Resident CD8+ T Cells as Mediators of Protective Immunity in Breast Milk Transmission of Human Cytomegalovirus.The Journal of infectious diseases · 2025Article
- Breast milk induces the differentiation of monocytes into macrophages, promoting human cytomegalovirus infection.Journal of virology · 2024Article
- Article
- Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection.American journal of perinatology · 2021Article
- Review
- Breast Milk and COVID-19: What Do We Know?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Impact of breast milk-acquired cytomegalovirus infection in premature infants: Pathogenesis, prevention, and clinical consequences?Reviews in medical virology · 2020Review
- Human Cytomegalovirus Reactivation During Lactation: Impact of Antibody Kinetics and Neutralization in Blood and Breast Milk.Nutrients · 2020Article
- Humoral Immune Correlates for Prevention of Postnatal Cytomegalovirus Acquisition.The Journal of infectious diseases · 2019Article
- Human Breast Milk-acquired Cytomegalovirus Infection: Certainties, Doubts and Perspectives.Current pediatric reviews · 2019Review
- Breast Milk Prefusion F Immunoglobulin G as a Correlate of Protection Against Respiratory Syncytial Virus Acute Respiratory Illness.The Journal of infectious diseases · 2019Article
- Natural history of postnatal rhesus cytomegalovirus shedding by dams and acquisition by infant rhesus monkeys.PloS one · 2018Article
- Breast Milk Human Cytomegalovirus (CMV) Viral Load and the Establishment of Breast Milk CMV-pp65-Specific CD8 T Cells in Human CMV Infected Mothers.The Journal of infectious diseases · 2017Article
- [Research advances in breast milk-acquired cytomegalovirus infection in premature infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
- Cross-sectional study of cytomegalovirus shedding and immunological markers among seropositive children and their mothers.BMC infectious diseases · 2014Article
- Immunity to cytomegalovirus in early life.Frontiers in immunology · 2014Review
- Postnatal cytomegalovirus exposure in infants of antiretroviral-treated and untreated HIV-infected mothers.Infectious diseases in obstetrics and gynecology · 2014Article
- The impact of differential antiviral immunity in children and adults.Nature reviews. Immunology · 2012Review
Corrections and comments
- Erratum issuedPuopolo, Karen P [corrected to Puopolo, Karen M]
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
introductionTransmission of cytomegalovirus (CMV) via breast milk can lead to severe acute illness in very low-birth-weight (VLBW) preterm infants. Although the majority of CMV-seropositive women shed CMV in milk, symptomatic postnatal infection of VLBW infants occurs infrequently, suggesting that virologic or immunologic factors in milk may be associated with the risk and severity of postnatal CMV infection.
methodsWe investigated the magnitude of CMV-specific cellular and humoral immune responses in milk of 30 seropositive mothers of VLWB preterm infants and assessed their relationship to milk CMV load and symptomatic CMV transmission.
resultsMilk immunoglobulin G (IgG) avidity was inversely correlated to milk CMV load (r = -0.47; P = .009). However, milk CMV load and CMV-specific cellular and humoral immune responses were similar in mothers of VLBW infants with and those without symptomatic postnatal CMV infection.
conclusionsSimilar immunologic parameters in milk of CMV-seropositive mothers of VLBW infants with and without symptomatic postnatal CMV infection indicate that screening milk by these parameters may not predict disease risk. However, the inverse correlation between milk CMV IgG avidity and CMV load may suggest that enhancement of maternal CMV-specific IgG responses could aid in reduction of CMV shedding into breast milk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.