ReviewCellular and molecular life sciences : CMLS2011
Expression and functional importance of innate immune receptors by intestinal epithelial cells.
Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Branched-chain amino acids and gut microbiota: coregulation and impact on neurological function via the gut-brain axis.Gut microbes · 2026Review
- Host-Microbiome Immune Interaction Networks: A Comparative Evolutionary Perspective Across Worms, Mice, and Humans.Pathogens (Basel, Switzerland) · 2026Review
- Modulation of oral vaccine efficacy by the gut microbiota.NPJ vaccines · 2025Review
- Global transcriptional analysis of human FHs 74 Int intestinal epithelial cells after exposure to advanced glycation end products.PloS one · 2025Article
- The localization of Toll and Imd pathway and complement system components and their response to Vibrio infection in the nemertean Lineus ruber.BMC biology · 2023Article
- Supplementation with postbiotic fromFrontiers in microbiology · 2023Article
- The immunity protection of intestine induced by pseudorabies virus del gI/gE/TK in piglets.Frontiers in microbiology · 2023Article
- Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases.Frontiers in microbiology · 2022Review
- The impact of selected food additives on the gastrointestinal tract in the example of nonspecific inflammatory bowel diseases.Archives of medical science : AMS · 2022Article
- Article
- Interferon b drives intestinal regeneration after radiation.Science advances · 2021Article
- Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains.PLoS biology · 2019Article
- Colorectal cancer prevention: Immune modulation taking the stage.Biochimica et biophysica acta. Reviews on cancer · 2018Review
- Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine.Cold Spring Harbor perspectives in biology · 2017Review
- Cytokine responses and epithelial function in the intestinal mucosa.Cellular and molecular life sciences : CMLS · 2016Review
- Contributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.Immunology letters · 2014Review
- Flavonoids Affect Host-Microbiota Crosstalk through TLR Modulation.Antioxidants (Basel, Switzerland) · 2014Review
- Gut commensal bacteria and regional Wnt gene expression in the proximal versus distal colon.The American journal of pathology · 2014Article
- Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism.Brain, behavior, and immunity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pattern recognition receptors are somatically encoded and participate in the innate immune responses of a host to microbes. It is increasingly acknowledged that these receptors play a central role both in beneficial and pathogenic interactions with microbes. In particular, these receptors participate actively in shaping the gut environment to establish a fruitful life-long relationship between a host and its microbiota. Commensal bacteria engage Toll-like receptors (TLRs) and nucleotide oligomerization domain (NOD)-like receptors (NLRs) to induce specific responses by intestinal epithelial cells such as production of antimicrobial products or of a functional mucus layer. Furthermore, a complex crosstalk between intestinal epithelial cells and the immune system is initiated leading to a mature gut-associated lymphoid tissue to secrete IgA. Impairment in NLR and TLR functionality in epithelial cells is strongly associated with chronic inflammatory diseases such as Crohn's disease, cancer, and with control of the commensal microbiota creating a more favorable environment for the emergence of new infections.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.