ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2012
Estimating individual glomerular volume in the human kidney: clinical perspectives.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Biopsy Morphometrics as Predictors of Treatment Response in Primary Nephrotic Syndrome.Kidney medicine · 2026Article
- Mechanisms of Diabetic Nephropathy Not Mediated by Hyperglycemia.Journal of clinical medicine · 2023Review
- Comparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruli.Physiological reports · 2023Article
- The Beneficial Effects of Bariatric-Surgery-Induced Weight Loss on Renal Function.Metabolites · 2022Review
- Quantitative morphometrics reveals glomerular changes in patients with infrequent segmentally sclerosed glomeruli.Journal of clinical pathology · 2022Article
- Low birth weight associates with glomerular area in young male IgA nephropathy patients.BMC nephrology · 2018Article
- Clinical and Pathology Findings Associate Consistently with Larger Glomerular Volume.Journal of the American Society of Nephrology : JASN · 2018Article
- Relationship of renal morphology on 3-dimensional ultrasonography with renal pathologic findings and outcome in biopsy-proven nephropathy.Experimental and therapeutic medicine · 2018Article
- The Renal Pathology of Obesity.Kidney international reports · 2017Review
- Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among Apparently Healthy Adults.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016Article
- Podocyte Number in Children and Adults: Associations with Glomerular Size and Numbers of Other Glomerular Resident Cells.Journal of the American Society of Nephrology : JASN · 2015Article
- Glomerular hypertrophy in subjects with low nephron number: contributions of sex, body size and race.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Article
- Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Article
- MRI-based glomerular morphology and pathology in whole human kidneys.American journal of physiology. Renal physiology · 2014Article
- The emerging role of MRI in quantitative renal glomerular morphology.American journal of physiology. Renal physiology · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundMeasurement of individual glomerular volumes (IGV) has allowed the identification of drivers of glomerular hypertrophy in subjects without overt renal pathology. This study aims to highlight the relevance of IGV measurements with possible clinical implications and determine how many profiles must be measured in order to achieve stable size distribution estimates.
methodsWe re-analysed 2250 IGV estimates obtained using the disector/Cavalieri method in 41 African and 34 Caucasian Americans. Pooled IGV analysis of mean and variance was conducted. Monte-Carlo (Jackknife) simulations determined the effect of the number of sampled glomeruli on mean IGV. Lin's concordance coefficient (R(C)), coefficient of variation (CV) and coefficient of error (CE) measured reliability.
resultsIGV mean and variance increased with overweight and hypertensive status. Superficial glomeruli were significantly smaller than juxtamedullary glomeruli in all subjects (P < 0.01), by race (P < 0.05) and in obese individuals (P < 0.01). Subjects with multiple chronic kidney disease (CKD) comorbidities showed significant increases in IGV mean and variability. Overall, mean IGV was particularly reliable with nine or more sampled glomeruli (R(C) > 0.95, <5% difference in CV and CE). These observations were not affected by a reduced sample size and did not disrupt the inverse linear correlation between mean IGV and estimated total glomerular number.
conclusionsMultiple comorbidities for CKD are associated with increased IGV mean and variance within subjects, including overweight, obesity and hypertension. Zonal selection and the number of sampled glomeruli do not represent drawbacks for future longitudinal biopsy-based studies of glomerular size and distribution.
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