ArticleIEEE transactions on bio-medical engineering2012
A novel methodology for assessing the bounded-input bounded-output instability in QT interval dynamics: application to clinical ECG with ventricular tachycardia.
Article in IEEE transactions on bio-medical engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical applications of QT/RR hysteresis assessment: A systematic review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2018Pooled it
- Stability analysis on the effects of heart rate variability and premature activation of atrial ECG dynamics using ARMAX model.Physical and engineering sciences in medicine · 2020Article
- Categorization and theoretical comparison of quantitative methods for assessing QT/RR hysteresis.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2017Review
- How computer simulations of the human heart can improve anti-arrhythmia therapy.The Journal of physiology · 2016Review
- Rate-dependent force, intracellular calcium, and action potential voltage alternans are modulated by sarcomere length and heart failure induced-remodeling of thin filament regulation in human heart failure: A myocyte modeling study.Progress in biophysics and molecular biology · 2016Article
- Arrhythmia risk stratification based on QT interval instability: an intracardiac electrocardiogram study.Heart rhythm · 2013Article
- Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2012Review
- Computational cardiology: the heart of the matter.ISRN cardiology · 2012Article
- Advances in modeling ventricular arrhythmias: from mechanisms to the clinic.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Abstract
The goal of this paper is to present a new methodology for assessing the bounded-input bounded-output (BIBO) stability in QT interval (QTI) dynamics from clinical ECG. The ECG recordings were collected from 15 patients who experienced ventricular tachycardia (VT). Ten-minute-long ECG recordings extracted immediately before the onset of a chosen VT, one per patient, were assembled into a VT group, while the control group comprised 10-min-long ECGs extracted 1 h before VT onset and at least 1 h after any prior arrhythmic event. Each 10-min recording was subdivided into 1-min ECG recordings (minECGs). The QTI dynamics of each minECG was defined as a function of several prior QTIs and RR intervals; the BIBO stability of this function was then assessed in the z -domain. The number of minECGs with unstable QTI dynamics (N (us)) and the frequency of premature activations (PA), f (PA) , were counted for each ECG recording and were compared between the VT and control groups. The results show that the present methodology successfully captured the instability in QTI dynamics leading to VT onset in the studied population. Significantly larger N (us) was found in the VT group compared against the control and a positive correlation between N (us) and f (PA) was identified in both groups.
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