ArticleToxicological sciences : an official journal of the Society of Toxicology2012
Low-dose inorganic mercury increases severity and frequency of chronic coxsackievirus-induced autoimmune myocarditis in mice.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Pooled it
- Exploring Trace Metal Imbalances: Serum Levels of Zinc, Selenium, Copper, Lead, Cadmium, and Mercury, and their Ratios in Acne Vulgaris Patients: An Analytical Cross-sectional Study.Indian dermatology online journal · 2025Article
- Association of Blood Total Mercury with Dyslipidemia in a sample of U.S. Adolescents: Results from the National Health and Nutrition Examination Survey Database, 2011-2018.Hygiene and environmental health advances · 2023Article
- Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges.Frontiers in pharmacology · 2020Review
- Modulators of mercury risk to wildlife and humans in the context of rapid global change.Ambio · 2018Article
- Synthesis and anti-myocarditis activity in a multifunctional lanthanide microporous metal-organic framework with 1D helical chain building units.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Mercury alters endogenous phosphorylation profiles of SYK in murine B cells.BMC immunology · 2017Article
- Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans.DNA repair · 2017Article
- Contribution of environmental toxins in the pathogenesis of idiopathic cardiomyopathies.Current treatment options in cardiovascular medicine · 2015Article
- Low-dose mercury heightens early innate response to coxsackievirus infection in female mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- A systems toxicology approach identifies Lyn as a key signaling phosphoprotein modulated by mercury in a B lymphocyte cell model.Toxicology and applied pharmacology · 2014Article
- Article
- Apocynin prevents vascular effects caused by chronic exposure to low concentrations of mercury.PloS one · 2013Article
- Update on coxsackievirus B3 myocarditis.Current opinion in rheumatology · 2012Review
- Gender differences in autoimmunity associated with exposure to environmental factors.Journal of autoimmunity · 2012Review
- A niche for infectious disease in environmental health: rethinking the toxicological paradigm.Environmental health perspectives · 2010Review
- Vitamin E andDose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mercury is a widespread environmental contaminant with neurotoxic impacts that have been observed over a range of exposures. In addition, there is increasing evidence that inorganic mercury (iHg) and organic mercury (including methyl mercury) have a range of immunotoxic effects, including immune suppression and induction of autoimmunity. In this study, we investigated the effect of iHg on a model of autoimmune heart disease in mice induced by infection with coxsackievirus B3 (CVB3). We examined the role of timing of iHg exposure on disease; in some experiments, mice were pretreated with iHg (200 μg/kg, every other day for 15 days) before disease induction with virus inoculation, and in others, they were treated with iHg after the acute (viral) phase of disease but before the development of dilated cardiomyopathy (DCM). iHg alone had no effect on heart pathology. Pretreatment with iHg before CVB3 infection significantly increased the severity of chronic myocarditis and DCM compared with control animals receiving vehicle alone. In contrast, treatment with iHg after acute myocarditis did not affect the severity of chronic disease. The increased chronic myocarditis, fibrosis, and DCM induced by iHg pretreatment were not due to increased viral replication in the heart, which was unaltered by iHg treatment. iHg pretreatment induced a macrophage infiltrate and mixed cytokine response in the heart during acute myocarditis, including significantly increased interleukin (IL)-12, IL-17, interferon-γ, and tumor necrosis factor-α levels. IL-17 levels were also significantly increased in the spleen during chronic disease. Thus, we show for the first time that low-dose Hg exposure increases chronic myocarditis and DCM in a murine model.
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Registered trials
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