ArticleCirculation. Arrhythmia and electrophysiology2011
Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system.
Article in Circulation. Arrhythmia and electrophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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32 citing papers in PubMed, 50 citations in OpenAlex.
- Tyrosine phosphorylation of Kir6.2 subunit negatively regulates cardiac KBasic research in cardiology · 2025Article
- Exploring the Role of Microplasma for Controlling Cellular Senescence inMolecules (Basel, Switzerland) · 2025Article
- Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration.Scientific reports · 2023Article
- Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS.EMBO molecular medicine · 2023Article
- The ATP sensitive potassium channel (KFrontiers in molecular neuroscience · 2023Review
- Review
- Kir6.1 and SUR2B in Cantú syndrome.American journal of physiology. Cell physiology · 2022Review
- ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential.Cells · 2022Review
- Ankyrin-G mediates targeting of both NaeLife · 2020Article
- Functional characterization of ABCC9 variants identified in sudden unexpected natural death.Forensic science international · 2019Article
- Genetic Discovery of ATP-Sensitive KCirculation. Arrhythmia and electrophysiology · 2019Review
- Cardiovascular consequences of KATP overactivity in Cantu syndrome.JCI insight · 2018Article
- ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia.The Journal of biological chemistry · 2018Article
- Potassium channels in the sinoatrial node and their role in heart rate control.Channels (Austin, Tex.) · 2018Review
- Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate-sensitive potassium channel subunit Kir6.1.The Journal of surgical research · 2016Article
- Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection.Cardiac electrophysiology clinics · 2016Review
- Angular Approach Scanning Ion Conductance Microscopy.Biophysical journal · 2016Article
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- Electrophysiologic consequences of KATP gain of function in the heart: Conduction abnormalities in Cantu syndrome.Heart rhythm · 2015Article
- Cantú syndrome resulting from activating mutation in the KCNJ8 gene.Human mutation · 2014Article
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8 authors at 1 institution in 1 country.
Funding
Abstract
Background- The specialized cardiac conduction system (CCS) expresses a unique complement of ion channels that confer a specific electrophysiological profile. ATP-sensitive potassium (K(ATP)) channels in these myocytes have not been systemically investigated. Methods and Results- We recorded K(ATP) channels in isolated CCS myocytes using Cntn2-EGFP reporter mice. The CCS K(ATP) channels were less sensitive to inhibitory cytosolic ATP compared with ventricular channels and more strongly activated by MgADP. They also had a smaller slope conductance. The 2 types of channels had similar intraburst open and closed times, but the CCS K(ATP) channel had a prolonged interburst closed time. CCS K(ATP) channels were strongly activated by diazoxide and less by levcromakalim, whereas the ventricular K(ATP) channel had a reverse pharmacological profile. CCS myocytes express elevated levels of Kir6.1 but reduced Kir6.2 and SUR2A mRNA compared with ventricular myocytes (SUR1 expression was negligible). SUR2B mRNA expression was higher in CCS myocytes relative to SUR2A. Canine Purkinje fibers expressed higher levels of Kir6.1 and SUR2B protein relative to the ventricle. Numeric simulation predicts a high sensitivity of the Purkinje action potential to changes in ATP:ADP ratio. Cardiac conduction time was prolonged by low-flow ischemia in isolated, perfused mouse hearts, which was prevented by glibenclamide. Conclusions- These data imply a differential electrophysiological response (and possible contribution to arrhythmias) of the ventricular CCS to K(ATP) channel opening during periods of ischemia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.