ArticleDigestive diseases and sciences2012
Circulating vitamin D and colorectal adenoma in asymptomatic average-risk individuals who underwent first screening colonoscopy: a case-control study.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Pooled it
- Circulating levels of vitamin D and colorectal adenoma: A case-control study and a meta-analysis.World journal of gastroenterology · 2015Pooled it
- Associations between circulating 1,25(OH)₂D concentration and odds of metachronous colorectal adenoma.Cancer causes & control : CCC · 2014Trial
- Vitamin D intake as well as circulating 25-hydroxyvitamin D level and risk for the incidence and recurrence of colorectal cancer precursors: A meta-analysis.Frontiers in medicine · 2022Article
- Review
- Vitamin D deficiency in theDisease models & mechanisms · 2018Article
- Vitamin D Deficiency Adds an Element of Risk to Insulin Resistance in Colorectal Neoplasms.Digestive diseases and sciences · 2015Article
- Cholecalciferol or 25-hydroxycholecalciferol neither prevents nor treats adenomas in a rat model of familial colon cancer.The Journal of nutrition · 2015Article
- Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans.Cancer causes & control : CCC · 2014Article
- BMI and the risk of colorectal adenoma in African-Americans.Obesity (Silver Spring, Md.) · 2014Article
- Association between circulating concentrations of 25(OH)D and colorectal adenoma: a pooled analysis.International journal of cancer · 2013Article
- Higher serum levels of vitamin D are associated with a reduced risk of diverticulitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013Article
- Functional role of microvesicles in gastrointestinal malignancies.Annals of translational medicine · 2013Article
- Using components of the vitamin D pathway to prevent and treat colon cancer.Nutrition reviews · 2012Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA higher circulating vitamin D level is inversely associated with the risk of colorectal cancer, but the association with adenoma risk is less clear.
aimsWe examined the association between the circulating 25-hydroxyvitamin D(3) [25(OH)D(3)] concentration and colorectal adenoma in asymptomatic average-risk participants undergoing initial screening colonoscopy.
methodsThe study subjects were comprised of 143 cases of colorectal adenomas and 143 age- and gender-matched controls with normal colonoscopy among the 586 asymptomatic average-risk subjects (median age, 58 years; range, 50-73 years) who underwent first screening colonoscopy and measurement of the serum 25(OH)D(3) between December 2009 and April 2010, consistent with winter months of the region.
resultsThe mean concentration of serum 25(OH)D(3) in the adenoma and control groups was 20.0 ± 11.0 ng/ml and 25.0 ± 20.0 ng/ml, respectively (P = 0.009). Using multivariate analysis, higher levels of 25(OH)D(3) were associated with a statistically significant decreased risk of colorectal adenoma after multivariable adjustment (highest vs. lowest quartile OR 0.38, 95% CI 0.18-0.80, P (trend) = 0.012). The inverse association of circulating 25(OH)D(3) with colorectal adenoma was stronger among the patients with proximal adenoma than that among the patients without proximal adenoma (highest vs. lowest quartile OR 0.29, 95% CI 0.13-0.66, P (trend) = 0.001).
conclusionsThe present study suggests that high levels of circulating vitamin D are associated with a decreased risk of colorectal adenoma, and especially adenoma located in the proximal colon.
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