ReviewDigestive diseases and sciences2011
Molecular mechanisms of Barrett's esophagus.
Review in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Gastroesophageal reflux disease and osteoporosis: A bidirectional Mendelian randomization study.Medicine · 2025Article
- Molecules involved in the development of Barrett's esophagus phenotype in chronic eosinophilic esophagitis.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Barrett's Oesophagus: Today's Mistake and Tomorrow's Wisdom in Screening and Prevention.Visceral medicine · 2022Review
- P63 Deficiency and CDX2 Overexpression Lead to Barrett's-Like Metaplasia in Mouse Esophageal Epithelium.Digestive diseases and sciences · 2021Article
- SPT6 loss permits the transdifferentiation of keratinocytes into an intestinal fate that resembles Barrett's metaplasia.iScience · 2021Article
- NOTCH and Esophageal Squamous Cell Carcinoma.Advances in experimental medicine and biology · 2021Review
- Distinct esophageal adenocarcinoma molecular subtype has subtype-specific gene expression and mutation patterns.BMC genomics · 2018Article
- microRNA involvement in the onset and progression of Barrett's esophagus: a systematic review.Oncotarget · 2018Review
- Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal Evolution.Medicines (Basel, Switzerland) · 2017Review
- Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia.The Journal of clinical investigation · 2014Article
- Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus.Digestive diseases and sciences · 2014Article
- Oral bisphosphonates and the risk of Barrett's esophagus: case-control analysis of US veterans.The American journal of gastroenterology · 2013Article
- Transgenic overexpression of cdx1b induces metaplastic changes of gene expression in zebrafish esophageal squamous epithelium.Zebrafish · 2013Article
- GERD-Barrett-Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers?Gastroenterology research and practice · 2013Article
- Management strategies of Barrett's esophagus.World journal of gastroenterology · 2012Review
- A surprise cell of origin for Barrett's esophagus.Cancer biology & therapy · 2012Article
- Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Barrett's esophagus (BE) is defined as the metaplastic conversion of esophageal squamous epithelium to intestinalized columnar epithelium. As a premalignant lesion of esophageal adenocarcinoma (EAC), BE develops as a result of chronic gastroesophageal reflux disease (GERD). Many studies have been conducted to understand the molecular mechanisms of this disease. This review summarizes recent results involving squamous and intestinal transcription factors, signaling pathways, stromal factors, microRNAs, and other factors in the development of BE. A conceptual framework is proposed to guide future studies. We expect elucidation of the molecular mechanisms of BE to help in the development of improved management of GERD, BE, and EAC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.