ReviewCurrent neurology and neuroscience reports2012
Pain disorders and erythromelalgia caused by voltage-gated sodium channel mutations.
Review in Current neurology and neuroscience reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Comparative Efficacy and Tolerability of Treatments for Erythromelalgia: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Cross-cultural evidence that shame is a defense against reputational damage.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Thalamic CGRP neurons define a spinothalamic pathway for affective pain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve.Channels (Austin, Tex.) · 2022Article
- [Functional vascular acrosyndromes].Innere Medizin (Heidelberg, Germany) · 2022Review
- A case of sporadic erythromelalgia presenting with small fibre neuropathy.BMJ case reports · 2019Article
- Current pain management strategies for patients with erythromelalgia: a critical review.Journal of pain research · 2018Review
- Advanced Genetic Testing Comes to the Pain Clinic to Make a Diagnosis of Paroxysmal Extreme Pain Disorder.Case reports in neurological medicine · 2016Article
- Mutational consequences of aberrant ion channels in neurological disorders.The Journal of membrane biology · 2014Review
- The fundamental unit of pain is the cell.Pain · 2013Review
- Article
- The perception and endogenous modulation of pain.Scientifica · 2012Review
- Erythromelalgia: a cutaneous manifestation of neuropathy?Anais brasileiros de dermatologiaReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-gated sodium channels play a pivotal role in pain transmission. They are widely expressed in nociceptive neurons, and participate in the generation of action potentials. Alteration in ionic conduction of these channels causes abnormal electrical firing, thus renders neurons hyperexcitable. So far, mutations in the Na(v)1.7 sodium channel, which is expressed in the dorsal root ganglia cells and sympathetic neurons, have been described to cause perturbations in pain sensation. Until recently, gain-of-function Na(v)1.7 mutations were known to cause two neuropathic pain syndromes: inherited erythromelalgia and paroxysmal extreme pain syndrome. These syndromes are inherited in a dominant trait; they usually begin in childhood or infancy, and are characterized by attacks of severe neuropathic pain accompanied with autonomic symptoms. Recently, small fiber neuropathy and chronic nonparoxysmal pain have been described in patients harboring gain-of-function mutations in Na(v)1.7 channel. Loss-of-function mutations in Na(v)1.7 are extremely rare, and invariably cause congenital inability to perceive pain.
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Registered trials
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